Wallensteen M, Ginsburg B E, Persson B, Dahlquist G
Department of Paediatrics, Karolinska Institute, St Göran's Children's Hospital, Stockholm, Sweden.
Acta Paediatr Scand. 1991 May;80(5):521-6. doi: 10.1111/j.1651-2227.1991.tb11896.x.
To assess the total insulin secretion in children in different nutritional states we have analysed the 24 h urinary C-peptide excretion in 32 obese children (16 boys and 16 girls) 8-15 years of age as well as in 7 girls with anorexia nervosa 11-16 years of age. Obese children had a median urinary C-peptide excretion rate of 0.27 nmol/kg/24 h, which was not different from that of a group of normal-weight children. In the group of anorectic girls, on the other hand, the median value 0.47 nmol/kg/24 h was significantly (p less than 0.05) higher than for normal-weight girls of the same age (median = 0.26 nmol/kg/24 h). These results indicate that in obese children insulin secretion, measured as the 24 h urinary C-peptide excretion per kg body weight, is the same as in normal-weight children. Total insulin secretion is consequently increased. In anorexia nervosa, on the other hand, the higher C-peptide excretion per kg body weight compared with normal-weight children, indicates that insulin secretion is increased in relation to body weight.
为评估不同营养状态儿童的胰岛素总分泌情况，我们分析了32名8至15岁肥胖儿童（16名男孩和16名女孩）以及7名11至16岁神经性厌食女孩的24小时尿C肽排泄量。肥胖儿童的尿C肽排泄率中位数为0.27 nmol/kg/24小时，与一组正常体重儿童无异。另一方面，在神经性厌食女孩组中，中位数0.47 nmol/kg/24小时显著高于（p<0.05）同龄正常体重女孩（中位数=0.26 nmol/kg/24小时）。这些结果表明，以每千克体重24小时尿C肽排泄量衡量，肥胖儿童的胰岛素分泌与正常体重儿童相同。因此，胰岛素总分泌增加。另一方面，在神经性厌食症中，与正常体重儿童相比，每千克体重的C肽排泄量更高，表明胰岛素分泌相对于体重增加。
