Kobaku Sai P R, Snyder Catherine S, Karunakaran Raghuraman G, Kwon Gibum, Wong Philip, Tuteja Anish, Mehta Geeta
ACS Macro Lett. 2019 Nov 19;8(11):1491-1497. doi: 10.1021/acsmacrolett.9b00493. Epub 2019 Oct 25.
Fabrication of charged, multiphasic, polymeric micro- and nanoparticles with precise control over their composition, size, and shape is critical for developing the next generation of drug carriers for combinatorial therapies and theranostics. The addition of charged polyelectrolyte multilayers on the surface of polymeric particles can significantly improve their stability, targeting efficacy, drug-release kinetics, and their ability to encapsulate different drugs within a single particle. Many of the traditional methods for multilayer functionalization of multiphasic polymeric particles are time and energy intensive which significantly limits their scalability, and therefore therapeutic potential. In this work, we combine the bulk layer-by-layer polyelectrolyte application methodology with our previously developed technique of fabricating multiphasic polymeric particles on substrates with patterned wettability to synthesize biocompatible, monodisperse, Janus polymer-polyelectrolyte particles.
精确控制带电、多相聚合物微米和纳米颗粒的组成、尺寸和形状对于开发用于联合治疗和治疗诊断的下一代药物载体至关重要。在聚合物颗粒表面添加带电聚电解质多层膜可以显著提高其稳定性、靶向效果、药物释放动力学以及在单个颗粒内封装不同药物的能力。多相聚合物颗粒多层功能化的许多传统方法既耗时又耗能，这极大地限制了它们的可扩展性，进而限制了它们的治疗潜力。在这项工作中，我们将本体逐层聚电解质应用方法与我们之前开发的在具有图案化润湿性的基板上制造多相聚合物颗粒的技术相结合，以合成生物相容性、单分散的Janus聚合物 - 聚电解质颗粒。
