按需定制的纳米医学的规模化制造：喷涂辅助逐层功能化 PRINT 纳米颗粒。
Scalable manufacture of built-to-order nanomedicine: spray-assisted layer-by-layer functionalization of PRINT nanoparticles.
机构信息
Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
出版信息
Adv Mater. 2013 Sep 14;25(34):4707-13. doi: 10.1002/adma.201302025. Epub 2013 Jul 1.
Abstract
Scalable methods, PRINT particle fabrication, and spray-assisted Layer-by-Layer deposition are combined to generate uniform and functional nanotechnologies with precise control over composition, size, shape, and surface functionality. A modular and tunable approach towards design of built-to-order nanoparticle systems, spray coating on PRINT particles is demonstrated to achieve technologies capable of targeted interactions with cancer cells for applications in drug delivery.
摘要
可扩展方法、PRINT 粒子制造和喷雾辅助层层沉积相结合，可生成具有精确控制组成、大小、形状和表面功能的均匀且功能化的纳米技术。通过模块化和可调谐方法设计定制的纳米粒子系统，对 PRINT 粒子进行喷雾涂层，实现了与癌细胞进行靶向相互作用的技术，可应用于药物输送。
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