Ruan Hong, Zhou Li
Key Laboratory of New Processing Technology for Nonferrous Metal and Materials (Ministry of Education), Guangxi Key Laboratory of Optical and Electronic Materials and Devices, College of Materials Science and Engineering, Guilin University of Technology, Guilin, China.
Front Bioeng Biotechnol. 2022 May 16;10:909727. doi: 10.3389/fbioe.2022.909727. eCollection 2022.
The rapid industrialization has had a serious impact on the environment, leading to an increase in disease and healthcare problems. The development of simple and effective biosensors to achieve specific analyte detection and bioimaging can provide useful information for disease prevention and treatment. Sulfur quantum dots (SQDs), a new class of metal-free fluorescent nanomaterial, are being studied and applied in diagnostic fields such as bioimaging and biosensing due to their advantages of simple synthetic process, unique composition, ultrasmall size, adjustable fluorescence, and low toxicity. This minireview highlights the main synthetic methods to synthesize fluorescent SQDs and their recent progress in cell and tissue imaging, as well as detection of biomolecules, metal ions, and temperature. Finally, the future development and some critical challenges of SQDs as a fluorescent probe in the field of bioimaging and biosensing are also discussed.
快速工业化对环境产生了严重影响，导致疾病和医疗保健问题增多。开发简单有效的生物传感器以实现特定分析物检测和生物成像可为疾病预防和治疗提供有用信息。硫量子点（SQDs）作为一类新型无金属荧光纳米材料，因其合成过程简单、成分独特、尺寸超小、荧光可调及毒性低等优点，正被研究并应用于生物成像和生物传感等诊断领域。本综述重点介绍了合成荧光SQDs的主要方法及其在细胞和组织成像以及生物分子、金属离子和温度检测方面的最新进展。最后，还讨论了SQDs作为生物成像和生物传感领域荧光探针的未来发展及一些关键挑战。
