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Toll-like receptors, innate immune system, and lung diseases: a vital trilateral association.

作者信息

Patel Vyoma K, Paudel Keshav R, Shukla Shakti D, Liu Gang, Oliver Brian G, Hansbro Philip M, Dua Kamal

机构信息

Macular Disease Foundation, NSW 2000, Australia.

Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia.

出版信息

EXCLI J. 2022 Feb 25;21:519-523. doi: 10.17179/excli2022-4688. eCollection 2022.

DOI:10.17179/excli2022-4688
PMID:35651656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9149966/
Abstract
摘要

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Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1;321(2):L404-L415. doi: 10.1152/ajplung.00002.2021. Epub 2021 Jun 23.
2
TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines.Toll样受体2（TLR2）可识别严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的包膜蛋白以产生炎性细胞因子。
Nat Immunol. 2021 Jul;22(7):829-838. doi: 10.1038/s41590-021-00937-x. Epub 2021 May 7.
3
The Toll-Like Receptor 5 agonist flagellin prevents Non-typeable Haemophilus influenzae-induced infection in cigarette smoke-exposed mice.TLR5 激动剂鞭毛蛋白可预防香烟暴露小鼠感染流感嗜血杆菌。
PLoS One. 2021 Mar 30;16(3):e0236216. doi: 10.1371/journal.pone.0236216. eCollection 2021.
4
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study.TLR7 变异与男性 COVID-19 重症患者的相关性：巢式病例对照研究的结果。
Elife. 2021 Mar 2;10:e67569. doi: 10.7554/eLife.67569.
5
TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs.TLR2 介导的上呼吸道固有免疫反应的激活赋予肺部抗病毒保护作用。
JCI Insight. 2021 Mar 8;6(5):140267. doi: 10.1172/jci.insight.140267.
6
Rutin loaded liquid crystalline nanoparticles inhibit lipopolysaccharide induced oxidative stress and apoptosis in bronchial epithelial cells in vitro.芦丁负载液晶纳米粒抑制脂多糖诱导的支气管上皮细胞氧化应激和凋亡。
Toxicol In Vitro. 2020 Oct;68:104961. doi: 10.1016/j.tiv.2020.104961. Epub 2020 Aug 7.
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Activation of TLR7 and Innate Immunity as an Efficient Method Against COVID-19 Pandemic: Imiquimod as a Potential Therapy.激活TLR7与固有免疫作为对抗新冠疫情的有效方法：咪喹莫特作为一种潜在疗法
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Lipopolysaccharide induces steroid-resistant exacerbations in a mouse model of allergic airway disease collectively through IL-13 and pulmonary macrophage activation.脂多糖通过 IL-13 和肺巨噬细胞激活共同诱导变应性气道疾病小鼠模型中的类固醇耐药性加重。
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Front Physiol. 2017 Jul 19;8:508. doi: 10.3389/fphys.2017.00508. eCollection 2017.