Mirabile Giuseppe, Campo Chiara, Ettari Roberta, Aguennouz M'Hammed, Musolino Caterina, Allegra Alessandro
Department of Human Pathology in Adulthood and Childhood, University of Messina, Messina, Italy.
Department of Chemical, Biological, Pharmaceutical and Environmental Chemistry, University of Messina, Messina, Italy.
Curr Med Chem. 2022;29(38):5965-5978. doi: 10.2174/0929867329666220601142924.
The microenvironment of the tumor cells is central to its phenotypic modification. One of the essential elements of this milieu is thermal regulation. An augment in local temperature has been reported to augment the tumor cell's responsiveness to chemoand radiation treatment. Cold shock proteins are RNA/DNA binding proteins identified by the existence of one or more cold shock domains. In humans, the best studied components of this group of proteins are called Y-box binding proteins, such as Y-box binding protein-1 (YB-1), but several other proteins have been recognized. Biological functions of these proteins extend from the control of transcription, translation and splicing to the regulation of exosomal RNA content. Several findings correlate an altered cold shock protein expression profile with tumor diseases. In this review we summarize the data for a causative participation of cold shock proteins in cancer onset and diffusion. Furthermore, the possible use of cold shock proteins for diagnostics, prognosis, and as targets for cancer treatment is exposed.
肿瘤细胞的微环境对于其表型改变至关重要。这种微环境的一个基本要素是热调节。据报道，局部温度升高会增强肿瘤细胞对化疗和放疗的反应性。冷休克蛋白是通过存在一个或多个冷休克结构域而鉴定出的RNA/DNA结合蛋白。在人类中，这类蛋白质中研究得最透彻的成分被称为Y盒结合蛋白，如Y盒结合蛋白-1（YB-1），但也已识别出其他几种蛋白质。这些蛋白质的生物学功能从转录、翻译和剪接的控制延伸到外泌体RNA含量的调节。多项研究结果将冷休克蛋白表达谱的改变与肿瘤疾病联系起来。在本综述中，我们总结了冷休克蛋白在癌症发生和扩散中因果性参与的数据。此外，还探讨了冷休克蛋白在诊断、预后以及作为癌症治疗靶点方面的潜在用途。
