Shafer R B, Levine A S, Marlette J M, Morley J E
Am J Clin Nutr. 1987 Apr;45(4):744-7. doi: 10.1093/ajcn/45.4.744.
We studied the effects of xylitol, the pentose-sugar alcohol, on gastric emptying of the solid-food component of a complex meal. Gastric emptying was measured in human volunteers by utilizing a standardized radiolabeled scrambled-egg meal. After ingestion of 25 g xylitol, gastric emptying was markedly prolonged (T-1/2 58 +/- 5 min control vs 91 +/- 7 min after xylitol [p less than 0.01]). Since delayed gastric emptying may affect food intake, we evaluated the effects of xylitol on calorie intake. Food intake after oral preloading with water resulted in intake of 920 +/- 60 kcal vs 690 +/- 45 kcal after 25 g of xylitol. In contrast, a preload of glucose, fructose, or sucrose failed to suppress food intake. Although xylitol decreased food intake and also delayed gastric emptying, these effects may be unrelated. Our data suggest a role for xylitol as a potentially important agent in dietary control.
我们研究了戊糖醇木糖醇对复合餐固体食物成分胃排空的影响。通过使用标准化放射性标记的炒鸡蛋餐来测量人类志愿者的胃排空情况。摄入25克木糖醇后，胃排空明显延长（T-1/2：对照组为58±5分钟，木糖醇摄入后为91±7分钟 [p<0.01]）。由于胃排空延迟可能会影响食物摄入量，我们评估了木糖醇对卡路里摄入量的影响。口服预充水后食物摄入量为920±60千卡，而摄入25克木糖醇后为690±45千卡。相比之下，葡萄糖、果糖或蔗糖预充未能抑制食物摄入。尽管木糖醇减少了食物摄入并延迟了胃排空，但这些影响可能并无关联。我们的数据表明木糖醇作为饮食控制中一种潜在的重要物质具有一定作用。
