Department of Dermatology, University of Wisconsin, Madison, WI, USA.
Department of Biomedical Engineering, University of Wisconsin, Madison, WI, USA.
Nat Commun. 2022 Jun 2;13(1):3086. doi: 10.1038/s41467-022-30384-7.
Precision oncology continues to challenge the "one-size-fits-all" dogma. Under the precision oncology banner, cancer patients are screened for molecular tumor alterations that predict treatment response, ideally leading to optimal treatments. Functional assays that directly evaluate treatment efficacy on the patient's cells offer an alternative and complementary tool to improve the accuracy of precision oncology. Unfortunately, traditional Petri dish-based assays overlook much tumor complexity, limiting their potential as predictive functional biomarkers. Here, we review past applications of microfluidic systems for precision medicine and discuss the present and potential future role of functional microfluidic assays as treatment predictors.
精准肿瘤学继续挑战“一刀切”的教条。在精准肿瘤学的旗帜下，癌症患者接受了分子肿瘤改变的筛查，这些改变可预测治疗反应，理想情况下可提供最佳治疗。直接评估患者细胞治疗效果的功能检测为提高精准肿瘤学的准确性提供了一种替代和互补的工具。不幸的是，基于传统培养皿的检测方法忽略了许多肿瘤的复杂性，限制了它们作为预测功能生物标志物的潜力。在这里，我们回顾了过去微流控系统在精准医学中的应用，并讨论了功能微流控检测作为治疗预测因子的当前和潜在未来作用。
