Cerrahpasa Medical Faculty, Department of Internal Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Department of Dermatology, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
Clin Rheumatol. 2022 Sep;41(9):2875-2881. doi: 10.1007/s10067-022-06231-x. Epub 2022 Jun 2.
Amiodarone can be used in a variety of arrhythmias. Given its widespread use, the probability of clinicians encountering its cutaneous adverse effects is high. A few cases of amiodarone-induced cutaneous vasculitis were reported in the literature, probably because it is underdiagnosed in clinical practice. Indeed, amiodarone-related cutaneous reactions may present a wide range of manifestations and are sometimes difficult to diagnose. Herein, we report a case with a sizeable necrotic ulcer on the left lower leg shortly after amiodarone exposure. A rigorous diagnostic study was performed before concluding the diagnosis of amiodarone-induced cutaneous vasculitis, which showed the histopathological features of leukocytoclastic vasculitis. The lesion was almost completely healed by the third month of discontinuation of amiodarone. We did a literature search and found seven cases which were reported as leukocytoclastic or lymphocytic vasculitis. We reviewed previous cases and presented our case in comparison to prior cases.
胺碘酮可用于多种心律失常。鉴于其广泛的应用，临床医生遇到其皮肤不良反应的概率很高。文献中报道了几例胺碘酮引起的皮肤血管炎病例，可能是因为在临床实践中诊断不足。事实上，胺碘酮相关的皮肤反应可能表现出广泛的表现，有时难以诊断。在此，我们报告一例患者在接触胺碘酮后不久左小腿出现一个大的坏死性溃疡。在诊断胺碘酮诱导的皮肤血管炎之前，进行了严格的诊断研究，该研究显示白细胞碎裂性血管炎的组织病理学特征。停药后第三个月，病变几乎完全愈合。我们进行了文献检索，发现了七例报道为白细胞碎裂性或淋巴细胞血管炎的病例。我们回顾了以前的病例，并将我们的病例与以前的病例进行了比较。
