Department of Life Science and Biotechnology, Jadavpur University, 700032, Kolkata, India.
Department of Microbiology, Maulana Azad College, 700013, Kolkata, India.
Mol Biol Rep. 2022 Jul;49(7):7013-7024. doi: 10.1007/s11033-022-07514-x. Epub 2022 Jun 2.
Recent advances in exosome biology have revealed significant roles of exosome and their contents in intercellular communication. Among various exosomal content, long non-coding RNAs (lncRNAs), which have a large size (˃ 200 nt) and lack protein coding potential, are known to play key roles in intercellular communication and novel biomarkers of various metabolic disorders. Moreover, long non-coding RNAs are often involved in the regulation of various cellular processes such as autophagy, apoptosis, cell proliferation. On the other hand, autophagy is the central regulating point that controls the various metabolic functions of the body. This process is known to prevent diseases and promote longevity. Therefore, the present review discusses the relationship between diseases and autophagy, and also look into the biological functions of exosome-associated lncRNAs in regulating autophagy. Furthermore, this review will summarize some of the studies that provide novel insights into the pathogenesis of autophagy-related diseases followed by the non-canonical roles played by autophagy and related proteins in the development of exosome biogenesis.
外泌体生物学的最新进展揭示了外泌体及其内容物在细胞间通讯中的重要作用。在各种外泌体内容物中，长链非编码 RNA（lncRNA）具有较大的大小（>200nt）且缺乏蛋白编码潜能，已知其在细胞间通讯和各种代谢紊乱的新型生物标志物中发挥关键作用。此外，长链非编码 RNA 通常参与各种细胞过程的调节，如自噬、细胞凋亡、细胞增殖。另一方面，自噬是控制身体各种代谢功能的中央调节点。这个过程被认为可以预防疾病和促进长寿。因此，本综述讨论了疾病与自噬的关系，并研究了外泌体相关 lncRNA 在调节自噬中的生物学功能。此外，本综述将总结一些研究，这些研究为自噬相关疾病的发病机制提供了新的见解，并探讨了自噬和相关蛋白在囊泡生物发生中的非典型作用。
