外泌体长链非编码 RNA 在癌症中的多种作用。
Multiple Roles of Exosomal Long Noncoding RNAs in Cancers.
机构信息
Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.
Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, China.
出版信息
Biomed Res Int. 2019 Jul 7;2019:1460572. doi: 10.1155/2019/1460572. eCollection 2019.
Long noncoding RNAs (lncRNAs) are not transcriptional noise, as previously understood, but are currently considered to be multifunctional. Exosomes are derived from the internal multivesicular compartment and are extracellular vesicles (EVs) with diameters of 30-100 nm. Exosomes play significant roles in the intercellular exchange of information and material. Exosomal lncRNAs may be promising biomarkers for cancer diagnosis and potential targets for cancer therapies, since they are increasingly understood to be involved in tumorigenesis, tumor angiogenesis, and chemoresistance. This review mainly focuses on the roles of emerging exosomal lncRNAs in cancer. In addition, the biogenesis of exosomes, the functions of lncRNAs, and the mechanisms of lncRNAs in exosome-mediated cell-cell communication are also summarized.
长链非编码 RNA（lncRNAs）并非先前认为的转录噪音，而是当前被认为具有多功能性的 RNA。外泌体来源于内部多泡体，并作为细胞外囊泡（EVs）存在，其直径为 30-100nm。外泌体在细胞间信息和物质的交换中发挥着重要作用。外泌体 lncRNAs 可能成为癌症诊断的有前途的生物标志物和癌症治疗的潜在靶点，因为它们越来越被认为参与肿瘤发生、肿瘤血管生成和化疗耐药。本综述主要关注新兴的外泌体 lncRNAs 在癌症中的作用。此外，还总结了外泌体的生物发生、lncRNAs 的功能以及 lncRNAs 在外泌体介导的细胞间通讯中的作用机制。
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