Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, UK.
NHS England & NHS Improvement, North East and Yorkshire, Quarry Hill, Leeds, LS2 7UE, UK.
Sci Rep. 2022 Jun 2;12(1):9174. doi: 10.1038/s41598-022-13372-1.
Obesity causes increases in brachial systolic-blood-pressures (SBP), risks of type 2 diabetes (T2DM) and cardiovascular diseases (CVD). Brachial and ankle SBPs have differential relationship with T2DM and CVD. Our objective was to study the relationship of obesity measures with brachial and ankle SBPs. A population of 1098 adults (South Asians n = 699; 41.70% male and 58.3% female) were recruited over 5 years from primary care practices in England. Their four limbs SBPs were measured using Doppler machine and body-mass-index (BMI) and waist-to-height-ratio (WHtR) calculated. Linear regressions were performed between SBPs and obesity measures, after adjustments for sex, age, ethnicity, T2DM and CVD. The mean age of all participants was 51.3 (SD = 17.2), European was 57.7 (SD 17.2) and South Asian was 47.8 (SD = 16.1). The left posterior tibial [Beta = 1.179, P = 4.559 × 10] and the right posterior tibial SBP [Beta = 1.178, P = 1.114 × 10] most significantly associated with the BMI. In South Asians, although the left brachial [Beta = 25.775, P = 0.032] and right brachial SBP [Beta = 22.792, P = 0.045] were associated to the WHtR, the left posterior tibial SBP [Beta = 39.894, P = 0.023], association was the strongest. For the first time, we have demonstrated that ankle SBPs had significant association with generalised obesity than brachial systolic blood pressures (SBP), irrespective of ethnicity. However, with respect to visceral obesity, the association with ankle SBP was more significant in South Asians compared to Europeans.
肥胖会导致肱动脉收缩压（SBP）升高，增加 2 型糖尿病（T2DM）和心血管疾病（CVD）的风险。肱动脉和踝部 SBP 与 T2DM 和 CVD 存在不同的关系。我们的目的是研究肥胖指标与肱动脉和踝部 SBP 的关系。在英格兰的基层医疗机构，我们在 5 年内招募了 1098 名成年人（南亚人 n=699；41.70%为男性，58.3%为女性）。使用多普勒机器测量他们四肢的 SBP，并计算体重指数（BMI）和腰高比（WHtR）。在调整了性别、年龄、种族、T2DM 和 CVD 后，对 SBP 和肥胖指标进行了线性回归。所有参与者的平均年龄为 51.3（标准差=17.2），欧洲人为 57.7（标准差 17.2），南亚人为 47.8（标准差=16.1）。左胫骨后[Beta=1.179，P=4.559×10]和右胫骨后 SBP[Beta=1.178，P=1.114×10]与 BMI 最显著相关。在南亚人中，尽管左肱动脉[Beta=25.775，P=0.032]和右肱动脉 SBP[Beta=22.792，P=0.045]与 WHtR 相关，但左胫骨后 SBP[Beta=39.894，P=0.023]的相关性最强。这是我们第一次证明踝部 SBP 与一般肥胖的相关性强于肱动脉收缩压（SBP），且与种族无关。然而，就内脏肥胖而言，踝部 SBP 与南亚人的相关性比欧洲人更显著。
