Department of Cardiology, Dalian Municipal Central Hospital, Dalian, China.
Dalian Medical University, Dalian, China.
BMC Cardiovasc Disord. 2022 Jun 3;22(1):248. doi: 10.1186/s12872-022-02691-w.
Cellular and animal studies have shown that endoplasmic reticulum protein B (Nogo-B) is associated with hypertension, but that association has not been fully studied in humans. Therefore, the expression levels of Nogo-B were investigated in hypertensive patients.
The plasma Nogo-B levels of 74 patients with hypertension and 67 non-hypertensive patients were measured by enzyme-linked immunosorbent assay.
The plasma Nogo-B levels in the hypertensive group [523.43(411.41-746.79)] were higher than in the non-hypertensive group [380.29(281.57-462.13)] (P < 0.01). Pearson's correlation analysis indicated that systolic blood pressure and diastolic blood pressure were linearly and positively correlated with plasma Nogo-B levels. Multivariable logistic regression analysis was performed based on sex, age, BMI, smoking history, drinking history, and levels of TC, TG, LDL, and HDL. The results indicated that the plasma Nogo-B levels were independently associated with hypertension (OR = 1.007, 95%CI: 1.004-1.010, P < 0.01).
The present study suggests that hypertensive participants exhibited higher plasma Nogo-B levels than those without hypertension. Plasma Nogo-B levels are independently associated with hypertension.
细胞和动物研究表明内质网蛋白 B（Nogo-B）与高血压有关，但在人类中尚未对此关联进行充分研究。因此，本研究调查了高血压患者中 Nogo-B 的表达水平。
通过酶联免疫吸附试验测量了 74 例高血压患者和 67 例非高血压患者的血浆 Nogo-B 水平。
高血压组的血浆 Nogo-B 水平[523.43（411.41-746.79）]高于非高血压组[380.29（281.57-462.13）]（P < 0.01）。Pearson 相关分析表明收缩压和舒张压与血浆 Nogo-B 水平呈线性正相关。基于性别、年龄、BMI、吸烟史、饮酒史以及 TC、TG、LDL 和 HDL 水平进行多变量 logistic 回归分析。结果表明，血浆 Nogo-B 水平与高血压独立相关（OR = 1.007，95%CI：1.004-1.010，P < 0.01）。
本研究表明，高血压患者的血浆 Nogo-B 水平高于无高血压患者。血浆 Nogo-B 水平与高血压独立相关。
