颈围与血脂谱的关系：观察性研究的系统评价和荟萃分析。
Association between neck circumference and lipid profile: a systematic review and meta-analysis of observational studies.
机构信息
Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, 2348569, Iran.
Student Research Committee, School of Nutrition and Food Science, Department of Clinical Nutrition, Isfahan University of Medical Sciences, Isfahan, 2348569, Iran.
出版信息
Eur J Cardiovasc Nurs. 2021 Aug 20;20(6):588-603. doi: 10.1093/eurjcn/zvaa018.
AIMS
Previous studies suggested that neck circumference (NC) as a new, simple, and valuable tool for the measuring obesity. However, the results of studies regarding the relationship between blood lipids and neck circumference were inconsistent. Therefore, we aimed to perform a systematic review and meta-analysis to summarize the association between NC and lipid profiles in adults.
METHODS AND RESULTS
PubMed and Scopus electronic databases were searched until 30 June 2018 to find articles that reported the association between NC and blood lipids. Mean serum lipids and variables contributed to heterogeneity were extracted. Sources of inter-study heterogeneity were determined by subgroup analysis. Of 2490 publications identified, 33 studies were included in the qualitative and quantitative synthesis. We found an inverse correlation between NC and high-density lipoprotein cholesterol [HDL-C; overall Fisher's Z = -0.18; 95% confidence interval (CI): -0.21, -0.15]. Furthermore, we found positive associations between NC and total cholesterol (TC; overall Fisher's Z = 0.11; 95% CI = 0.06, 0.16), low-density lipoprotein cholesterol (LDL-C; overall Fisher's Z = 0.1; 95% CI = -0.04, 0.16), and triglyceride (TG; overall Fisher's Z = 0.21; 95% CI = 0.17, 0.25) in men. Neck circumference was directly correlated to TC (overall Fisher's Z = 0.1; 95% CI = 0.01, 0.19) and LDL-C (overall Fisher's Z = 0.16; 95% CI = 0.12, 0.20) in healthy and unhealthy women, respectively. There was no correlation between NC and serum concentration of TC (overall Fisher's Z = 0.01; 95% CI = -0.02, 0.03) and LDL-C (overall Fisher's Z = 0.09; 95% CI = 0.02, 0.16) in unhealthy and healthy women, respectively.
CONCLUSION
Higher NC in unhealthy men was strongly indirectly associated with HDL-C, and directly related to LDL-C, TG, and TC. In unhealthy women, higher NC was inversely associated with HDL and directly related to LDL-C.
目的
先前的研究表明，颈围（NC）是衡量肥胖的一种新的、简单且有价值的工具。然而，关于颈围与血脂之间关系的研究结果并不一致。因此，我们旨在进行系统评价和荟萃分析，以总结成年人颈围与血脂谱之间的关系。
方法和结果
我们检索了 PubMed 和 Scopus 电子数据库，以查找截至 2018 年 6 月 30 日报告颈围与血脂之间关系的文章。提取了平均血清脂质和导致异质性的变量。通过亚组分析确定研究间异质性的来源。在 2490 篇出版物中，有 33 项研究被纳入定性和定量综合分析。我们发现颈围与高密度脂蛋白胆固醇（HDL-C）之间呈负相关[总体 Fisher's Z = -0.18；95%置信区间（CI）：-0.21，-0.15]。此外，我们发现颈围与总胆固醇（TC；总体 Fisher's Z = 0.11；95%CI = 0.06，0.16）、低密度脂蛋白胆固醇（LDL-C；总体 Fisher's Z = 0.10；95%CI = -0.04，0.16）和甘油三酯（TG；总体 Fisher's Z = 0.21；95%CI = 0.17，0.25）之间存在正相关。在男性中，颈围与 TC（总体 Fisher's Z = 0.10；95%CI = 0.01，0.19）和 LDL-C（总体 Fisher's Z = 0.16；95%CI = 0.12，0.20）呈直接相关。在健康和不健康的女性中，颈围分别与 TC（总体 Fisher's Z = 0.01；95%CI = -0.02，0.03）和 LDL-C（总体 Fisher's Z = 0.09；95%CI = 0.02，0.16）呈负相关。
结论
不健康男性的颈围较高与 HDL-C 呈强烈的间接关联，与 LDL-C、TG 和 TC 呈直接关联。在不健康的女性中，颈围与 HDL-C 呈负相关，与 LDL-C 呈直接相关。
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