Yang Xinyu, Zhang Yanqi, Wang Xingyi, Chen Shiliang, Zheng Yang, Hou Xinyu, Wang Shiyu, Zheng Xianghui, Li Qifeng, Sun Yong, Wu Jian
Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin Medical University, Harbin, Heilongjiang, China.
Epigenomics. 2025 Feb;17(3):179-191. doi: 10.1080/17501911.2024.2447811. Epub 2024 Dec 30.
Cardiovascular diseases (CVDs) represent a prominent contributor to global morbidity and mortality rates, with projections indicating a rise in this burden due to population aging. While extensive research has underscored the efficacy of exercise in mitigating the risk of CVDs, the precise mechanisms, particularly within the realm of epigenetics, remain nascent. This article delves into cutting-edge research concerning exercise-induced epigenetic alterations and their impact on CVDs. Initially, we examine the cardiac implications stemming from exercise-induced epigenetic influences across varying intensities. Subsequently, our focus shifts toward delineating the mechanisms governing exercise-induced DNA methylation, lactylation modifications, and N6-methyladenosine (m6A) RNA modifications, alongside addressing associated challenges and outlining prospective research directions. These findings suggest that exercise-mediated epigenetic modifications offer promising therapeutic potential for the prevention and comorbidity management of CVDs. However, the heterogeneity and tissue specificity of these effects necessitate more targeted research to unlock their full therapeutic potential.
心血管疾病（CVDs）是全球发病率和死亡率的主要贡献因素，预计由于人口老龄化，这一负担将会增加。虽然广泛的研究强调了运动在降低心血管疾病风险方面的功效，但其确切机制，尤其是在表观遗传学领域，仍处于起步阶段。本文深入探讨了关于运动诱导的表观遗传改变及其对心血管疾病影响的前沿研究。首先，我们研究了不同强度运动诱导的表观遗传影响对心脏的影响。随后，我们的重点转向阐明运动诱导的DNA甲基化、乳酸化修饰和N6-甲基腺苷（m6A）RNA修饰的机制，同时解决相关挑战并概述未来的研究方向。这些发现表明，运动介导的表观遗传修饰为心血管疾病的预防和合并症管理提供了有前景的治疗潜力。然而，这些效应的异质性和组织特异性需要更有针对性的研究来充分发挥其治疗潜力。
