Department of Radiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou 362000, China.
Contrast Media Mol Imaging. 2022 May 18;2022:7242192. doi: 10.1155/2022/7242192. eCollection 2022.
Meningioma, glioma, and metastases are the most common intracranial tumors in clinical practice. In order to improve the prognosis of patients, timely diagnosis and early treatment are crucial. Hydrogen proton magnetic resonance spectroscopy (1H-MRS) imaging can noninvasively display the biochemical information of tissues and has been applied to identify and diagnose intracranial tumors. We want to comprehensively evaluate 1H-MRS identify and diagnose intracranial tumors by meta-analysis. Some databases such as PubMed and Cochrane Library were used to systematically search articles that were about identifying and diagnosing intracranial tumors with 1H-MRS. Then, weighted mean difference (WMD) was used as an effect size to conduct meta-analysis. There are altogether nine articles, including 533 patients. Results of meta-analysis: The Cho/Cr and Cho/NAA ratios in the LGG group were significantly lower than those in the HGG group (WMD = -0.69, 95% CI (-0.92, -0.45), < 0.001, WMD = -0.76, 95% CI (-1.03, -0.48), < 0.001). The Cho/Cr ratio of tumor and peritumor in the HGG group was significantly different from that in the metastasis group (0.68, 95% CI (-1.27, 2.62), < 0.001, WMD = 0.94, 95% CI (0.41, 1.47), < 0.001). There was no significant difference in the tumor and peritumor NAA/Cr ratio between the HGG group and metastasis group (WMD = -0.64, 95% CI (-1.63, 0.34), =0.31, WMD = -0.22, 95% CI (-0.59, 0.15), =0.24). 1H-MRS can provide metabolic information of different intracranial tumors and can effectively diagnose and differentiate glioma and metastasis. 1H-MRS can also provide a reliable basis for the classification of glioma, and has certain clinical application value.
脑膜瘤、神经胶质瘤和转移瘤是临床实践中最常见的颅内肿瘤。为了改善患者的预后，及时诊断和早期治疗至关重要。氢质子磁共振波谱（1H-MRS）成像可以无创地显示组织的生化信息，已被用于识别和诊断颅内肿瘤。我们希望通过荟萃分析全面评估 1H-MRS 对颅内肿瘤的识别和诊断能力。使用 PubMed 和 Cochrane Library 等数据库系统地搜索了关于使用 1H-MRS 识别和诊断颅内肿瘤的文章。然后，使用加权均数差（WMD）作为效应量进行荟萃分析。共有 9 篇文章，包括 533 名患者。荟萃分析结果：低级别神经胶质瘤（LGG）组的 Cho/Cr 和 Cho/NAA 比值明显低于高级别神经胶质瘤（HGG）组（WMD=-0.69，95%CI（-0.92，-0.45）， < 0.001，WMD=-0.76，95%CI（-1.03，-0.48）， < 0.001）。HGG 组肿瘤和瘤周的 Cho/Cr 比值与转移瘤组有显著差异（0.68，95%CI（-1.27，2.62）， < 0.001，WMD=0.94，95%CI（0.41，1.47）， < 0.001）。HGG 组肿瘤和瘤周的 NAA/Cr 比值与转移瘤组无显著差异（WMD=-0.64，95%CI（-1.63，0.34），=0.31，WMD=-0.22，95%CI（-0.59，0.15），=0.24）。1H-MRS 可以提供不同颅内肿瘤的代谢信息，有效诊断和区分神经胶质瘤和转移瘤。1H-MRS 还可以为神经胶质瘤的分类提供可靠的依据，具有一定的临床应用价值。
