• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

磁共振波谱、正电子发射断层扫描与放射基因组学——与胶质瘤的相关性

Magnetic Resonance Spectroscopy, Positron Emission Tomography and Radiogenomics-Relevance to Glioma.

作者信息

Chiang Gloria C, Kovanlikaya Ilhami, Choi Changho, Ramakrishna Rohan, Magge Rajiv, Shungu Dikoma C

机构信息

Department of Neuroradiology, Weill Cornell Medical College, New York, NY, United States.

Radiology, Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States.

出版信息

Front Neurol. 2018 Feb 5;9:33. doi: 10.3389/fneur.2018.00033. eCollection 2018.

DOI:10.3389/fneur.2018.00033
PMID:29459844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5807339/
Abstract

Advances in metabolic imaging techniques have allowed for more precise characterization of gliomas, particularly as it relates to tumor recurrence or pseudoprogression. Furthermore, the emerging field of radiogenomics where radiographic features are systemically correlated with molecular markers has the potential to achieve the holy grail of neuro-oncologic neuro-radiology, namely molecular diagnosis without requiring tissue specimens. In this section, we will review the utility of metabolic imaging and discuss the current state of the art related to the radiogenomics of glioblastoma.

摘要

代谢成像技术的进步使得对胶质瘤的特征描述更加精确，特别是在肿瘤复发或假性进展方面。此外，放射基因组学这一新兴领域将影像学特征与分子标志物进行系统关联，有潜力实现神经肿瘤神经放射学的圣杯，即无需组织标本即可进行分子诊断。在本节中，我们将回顾代谢成像的应用，并讨论与胶质母细胞瘤放射基因组学相关的当前技术水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/9849b3e6fa73/fneur-09-00033-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/fb522f3cb53f/fneur-09-00033-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/b70dd0bac133/fneur-09-00033-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/c46e4ae01957/fneur-09-00033-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/49d4fe485756/fneur-09-00033-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/9849b3e6fa73/fneur-09-00033-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/fb522f3cb53f/fneur-09-00033-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/b70dd0bac133/fneur-09-00033-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/c46e4ae01957/fneur-09-00033-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/49d4fe485756/fneur-09-00033-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/198b/5807339/9849b3e6fa73/fneur-09-00033-g005.jpg

相似文献

1
Magnetic Resonance Spectroscopy, Positron Emission Tomography and Radiogenomics-Relevance to Glioma.磁共振波谱、正电子发射断层扫描与放射基因组学——与胶质瘤的相关性
Front Neurol. 2018 Feb 5;9:33. doi: 10.3389/fneur.2018.00033. eCollection 2018.
2
Conventional and advanced imaging throughout the cycle of care of gliomas.在胶质瘤的整个治疗周期中的常规和先进成像技术。
Neurosurg Rev. 2021 Oct;44(5):2493-2509. doi: 10.1007/s10143-020-01448-3. Epub 2021 Jan 7.
3
Preoperative Diagnosis and Molecular Characterization of Gliomas With Liquid Biopsy and Radiogenomics.基于液体活检和放射基因组学的胶质瘤术前诊断及分子特征分析
Front Neurol. 2022 May 26;13:865171. doi: 10.3389/fneur.2022.865171. eCollection 2022.
4
Radiogenomic Predictors of Recurrence in Glioblastoma-A Systematic Review.胶质母细胞瘤复发的放射基因组预测指标——一项系统综述
J Pers Med. 2022 Mar 4;12(3):402. doi: 10.3390/jpm12030402.
5
Comparison of magnetic resonance spectroscopy and positron emission tomography in detection of tumor recurrence in posttreatment of glioma: A diagnostic meta-analysis.磁共振波谱与正电子发射断层扫描在胶质瘤治疗后肿瘤复发检测中的比较：一项诊断性荟萃分析。
Asia Pac J Clin Oncol. 2015 Jun;11(2):97-105. doi: 10.1111/ajco.12202. Epub 2014 May 1.
6
Comparison of O-(2-F-Fluoroethyl)-L-Tyrosine Positron Emission Tomography and Perfusion-Weighted Magnetic Resonance Imaging in the Diagnosis of Patients with Progressive and Recurrent Glioma: A Hybrid Positron Emission Tomography/Magnetic Resonance Study.O-(2-氟乙基)-L-酪氨酸正电子发射断层扫描与灌注加权磁共振成像在进展性和复发性胶质瘤患者诊断中的比较：一项正电子发射断层扫描/磁共振混合研究
World Neurosurg. 2018 May;113:e727-e737. doi: 10.1016/j.wneu.2018.02.139. Epub 2018 Mar 3.
7
Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy.脑胶质瘤的多模态代谢成像：[18F]氟乙基-L-酪氨酸正电子发射断层扫描与磁共振波谱分析
J Neurosurg. 2005 Feb;102(2):318-27. doi: 10.3171/jns.2005.102.2.0318.
8
Unsupervised consensus cluster analysis of [18F]-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis of pseudoprogression in high-grade glioma.[18F]-氟乙基-L-酪氨酸正电子发射断层扫描的无监督一致性聚类分析确定了用于诊断高级别胶质瘤假性进展的纹理特征。
Oncotarget. 2017 Jan 31;8(5):8294-8304. doi: 10.18632/oncotarget.14166.
9
Emerging Applications of Artificial Intelligence in Neuro-Oncology.人工智能在神经肿瘤学中的新兴应用。
Radiology. 2019 Mar;290(3):607-618. doi: 10.1148/radiol.2018181928. Epub 2019 Jan 22.
10
The Value of 5-Aminolevulinic Acid in Low-grade Gliomas and High-grade Gliomas Lacking Glioblastoma Imaging Features: An Analysis Based on Fluorescence, Magnetic Resonance Imaging, 18F-Fluoroethyl Tyrosine Positron Emission Tomography, and Tumor Molecular Factors.5-氨基酮戊酸在缺乏胶质母细胞瘤影像学特征的低级别胶质瘤和高级别胶质瘤中的价值：基于荧光、磁共振成像、18F-氟乙基酪氨酸正电子发射断层扫描及肿瘤分子因素的分析
Neurosurgery. 2016 Mar;78(3):401-11; discussion 411. doi: 10.1227/NEU.0000000000001020.

引用本文的文献

1
Advances in Glioblastoma Diagnosis: Integrating Genetics, Noninvasive Sampling, and Advanced Imaging.胶质母细胞瘤诊断的进展：整合遗传学、非侵入性采样和先进成像技术
Cancers (Basel). 2025 Jan 2;17(1):124. doi: 10.3390/cancers17010124.
2
Multiparametric Analysis Combining DSC-MR Perfusion and [18F]FET-PET is Superior to a Single Parameter Approach for Differentiation of Progressive Glioma from Radiation Necrosis.多参数分析结合 DSC-MR 灌注和 [18F]FET-PET 比单一参数方法更有助于鉴别进展性脑胶质瘤与放射性坏死。
Clin Neuroradiol. 2024 Jun;34(2):351-360. doi: 10.1007/s00062-023-01372-1. Epub 2023 Dec 29.
3
Astrocytoma Mimicking Herpetic Meningoencephalitis: The Role of Non-Invasive Multimodal Monitoring in Neurointensivism.

本文引用的文献

1
Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma.2-羟基戊二酸磁共振波谱的前瞻性纵向分析确定了IDH突变型胶质瘤患者管理的广泛临床应用价值。
J Clin Oncol. 2016 Nov 20;34(33):4030-4039. doi: 10.1200/JCO.2016.67.1222. Epub 2016 Oct 31.
2
Patterns of failure for patients with glioblastoma following O-(2-[F]fluoroethyl)-L-tyrosine PET- and MRI-guided radiotherapy.O-(2-[F]氟乙基)-L-酪氨酸 PET 和 MRI 引导放疗后胶质母细胞瘤患者的失败模式。
Radiother Oncol. 2017 Mar;122(3):380-386. doi: 10.1016/j.radonc.2017.01.002. Epub 2017 Jan 19.
3
酷似疱疹性脑膜脑炎的星形细胞瘤：非侵入性多模态监测在神经重症监护中的作用
Neurol Int. 2023 Nov 29;15(4):1403-1410. doi: 10.3390/neurolint15040090.
4
Research Progress of CXCR4-Targeting Radioligands for Oncologic Imaging.CXCR4 靶向放射性配体在肿瘤成像中的研究进展。
Korean J Radiol. 2023 Sep;24(9):871-889. doi: 10.3348/kjr.2023.0091.
5
Towards differentiation of brain tumor from radiation necrosis using multi-parametric MRI: Preliminary results at 4.7 T using rodent models.使用多参数 MRI 区分脑肿瘤与放射性坏死：在 4.7T 下使用啮齿动物模型的初步结果。
Magn Reson Imaging. 2022 Dec;94:144-150. doi: 10.1016/j.mri.2022.10.002. Epub 2022 Oct 6.
6
Radiomics analysis of amide proton transfer-weighted and structural MR images for treatment response assessment in malignant gliomas.酰胺质子转移加权和结构磁共振成像的放射组学分析在恶性胶质瘤治疗反应评估中的应用。
NMR Biomed. 2023 Jan;36(1):e4824. doi: 10.1002/nbm.4824. Epub 2022 Sep 24.
7
Selective Cell Size MRI Differentiates Brain Tumors from Radiation Necrosis.磁共振选择性细胞大小成像可区分脑肿瘤与放射性坏死。
Cancer Res. 2022 Oct 4;82(19):3603-3613. doi: 10.1158/0008-5472.CAN-21-2929.
8
Distinguishing Tumor Admixed in a Radiation Necrosis (RN) Background: H and H MR With a Novel Mouse Brain-Tumor/RN Model.鉴别混杂于放射性坏死（RN）背景中的肿瘤：采用新型小鼠脑肿瘤/RN模型的氢质子磁共振波谱分析（H and H MR）
Front Oncol. 2022 May 30;12:885480. doi: 10.3389/fonc.2022.885480. eCollection 2022.
9
Hydrogen Proton Magnetic Resonance Spectroscopy (MRS) in Differential Diagnosis of Intracranial Tumors: A Systematic Review.氢质子磁共振波谱（MRS）在颅内肿瘤鉴别诊断中的应用：系统评价。
Contrast Media Mol Imaging. 2022 May 18;2022:7242192. doi: 10.1155/2022/7242192. eCollection 2022.
10
Diagnostic Accuracy of Magnetic Resonance Spectroscopy in Predicting the Grade of Glioma Keeping Histopathology as the Gold Standard.以组织病理学为金标准时，磁共振波谱在预测胶质瘤分级中的诊断准确性
Cureus. 2022 Feb 9;14(2):e22056. doi: 10.7759/cureus.22056. eCollection 2022 Feb.
Changes in cerebral metabolism during ketogenic diet in patients with primary brain tumors: H-MRS study.
原发性脑肿瘤患者生酮饮食期间脑代谢的变化：氢质子磁共振波谱研究
J Neurooncol. 2017 Apr;132(2):267-275. doi: 10.1007/s11060-016-2364-x. Epub 2017 Jan 10.
4
Unsupervised consensus cluster analysis of [18F]-fluoroethyl-L-tyrosine positron emission tomography identified textural features for the diagnosis of pseudoprogression in high-grade glioma.[18F]-氟乙基-L-酪氨酸正电子发射断层扫描的无监督一致性聚类分析确定了用于诊断高级别胶质瘤假性进展的纹理特征。
Oncotarget. 2017 Jan 31;8(5):8294-8304. doi: 10.18632/oncotarget.14166.
5
Radiomics in Brain Tumors: An Emerging Technique for Characterization of Tumor Environment.脑肿瘤中的放射组学：一种用于表征肿瘤环境的新兴技术。
Magn Reson Imaging Clin N Am. 2016 Nov;24(4):719-729. doi: 10.1016/j.mric.2016.06.006.
6
Unravelling tumour heterogeneity using next-generation imaging: radiomics, radiogenomics, and habitat imaging.利用下一代成像技术解析肿瘤异质性：放射组学、放射基因组学和栖息地成像
Clin Radiol. 2017 Jan;72(1):3-10. doi: 10.1016/j.crad.2016.09.013. Epub 2016 Oct 11.
7
Amino-acid PET versus MRI guided re-irradiation in patients with recurrent glioblastoma multiforme (GLIAA) - protocol of a randomized phase II trial (NOA 10/ARO 2013-1).氨基酸正电子发射断层扫描（PET）与磁共振成像（MRI）引导下复发性多形性胶质母细胞瘤（GLIAA）患者再程放疗的比较——一项随机II期试验（NOA 10/ARO 2013-1）方案
BMC Cancer. 2016 Oct 5;16(1):769. doi: 10.1186/s12885-016-2806-z.
8
Radiogenomics of Glioblastoma: Machine Learning-based Classification of Molecular Characteristics by Using Multiparametric and Multiregional MR Imaging Features.脑胶质母细胞瘤的放射组学：基于机器学习的多参数多区域磁共振成像特征分子特征分类。
Radiology. 2016 Dec;281(3):907-918. doi: 10.1148/radiol.2016161382. Epub 2016 Sep 16.
9
The Added Prognostic Value of Metabolic Tumor Size on FDG-PET at First Suspected Recurrence of Glioblastoma Multiforme.代谢肿瘤大小在多形性胶质母细胞瘤首次怀疑复发时对氟代脱氧葡萄糖正电子发射断层扫描的附加预后价值
J Neuroimaging. 2017 Mar;27(2):243-247. doi: 10.1111/jon.12386. Epub 2016 Aug 12.
10
Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas.将基质金属蛋白酶-1（MT1-MMP）作为基于免疫正电子发射断层扫描（ImmunoPET）的胶质瘤成像策略的靶点。
PLoS One. 2016 Jul 27;11(7):e0158634. doi: 10.1371/journal.pone.0158634. eCollection 2016.