School of Life Sciences, Fudan University, Shanghai, China.
Department of Laboratory Animal Science, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Front Endocrinol (Lausanne). 2022 May 17;13:887843. doi: 10.3389/fendo.2022.887843. eCollection 2022.
High-salt diet (HSD) is associated with dysregulated metabolism and metabolic disorders. Although previous studies have indicated its effect on metabolic tissues, the involving molecular mechanisms are not quite understood. In the present study, we provided a comprehensive transcriptome analysis on multiple metabolic tissues of HSD-fed mouse model by RNA sequencing. We observed that several genes associated with lipogenesis and cholesterol biosynthesis were significantly downregulated in white adipose tissue and liver tissue of HSD mice group, such as , , , and Furthermore, combined with secretome datasets, our results further demonstrated that HSD could alter expression levels of organokines in metabolic tissues, for example, and , in liver tissue and, thus, possibly mediate cross-talk between different metabolic tissues. Our study provided new insight about molecular signatures of HSD on multiple metabolic tissues.
高盐饮食（HSD）与代谢紊乱和代谢紊乱有关。尽管先前的研究表明它对代谢组织有影响，但涉及的分子机制尚不完全清楚。在本研究中，我们通过 RNA 测序对 HSD 喂养的小鼠模型的多种代谢组织进行了全面的转录组分析。我们观察到，HSD 小鼠的白色脂肪组织和肝脏组织中与脂肪生成和胆固醇生物合成相关的几个基因显著下调，例如、、、和。此外，结合分泌组数据集，我们的结果进一步表明，HSD 可以改变代谢组织中器官因子的表达水平，例如肝脏组织中的和，因此可能介导不同代谢组织之间的串扰。我们的研究为 HSD 对多种代谢组织的分子特征提供了新的见解。
