Mill Jericha, Li Lingjun
Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706 USA.
School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705 USA.
Phenomics. 2022 Feb;2(1):1-17. doi: 10.1007/s43657-021-00036-9. Epub 2022 Feb 22.
Alzheimer's disease (AD) is the leading cause of dementia in the aging population, but despite extensive research, there is no consensus on the biological cause of AD. While AD research is dominated by protein/peptide-centric research based on the amyloid hypothesis, a theory that designates dysfunction in beta-amyloid production, accumulation, or disposal as the primary cause of AD, many studies focus on metabolomics as a means of understanding the biological processes behind AD progression. In this review, we discuss mass spectrometry (MS)-based AD metabolomics studies, including sample type and preparation, mass spectrometry specifications, and data analysis, as well as biological insights gleaned from these studies, with the hope of informing future AD metabolomic studies.
阿尔茨海默病（AD）是老年人群中痴呆症的主要病因，但尽管进行了广泛研究，关于AD的生物学病因仍未达成共识。虽然AD研究主要是基于淀粉样蛋白假说的以蛋白质/肽为中心的研究，该理论将β-淀粉样蛋白产生、积累或清除功能障碍指定为AD的主要病因，但许多研究将代谢组学作为理解AD进展背后生物学过程的一种手段。在本综述中，我们讨论基于质谱（MS）的AD代谢组学研究，包括样本类型和制备、质谱规格和数据分析，以及从这些研究中获得的生物学见解，希望为未来的AD代谢组学研究提供参考。
