• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

循环 S-谷胱甘肽化 cMyBP-C 作为心脏舒张功能障碍的生物标志物。

Circulating S-Glutathionylated cMyBP-C as a Biomarker for Cardiac Diastolic Dysfunction.

机构信息

Division of Cardiology Department of Medicine The Lillehei Heart InstituteUniversity of Minnesota Minneapolis MN.

Lifespan Cardiovascular Research Center Brown University Providence RI.

出版信息

J Am Heart Assoc. 2022 Jun 7;11(11):e025295. doi: 10.1161/JAHA.122.025295. Epub 2022 Jun 3.

DOI:10.1161/JAHA.122.025295
PMID:35656993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9238749/
Abstract

Background cMyBP-C (Cardiac myosin binding protein-C) regulates cardiac contraction and relaxation. Previously, we demonstrated that elevated myocardial S-glutathionylation of cMyBP-C correlates with diastolic dysfunction (DD) in animal models. In this study, we tested whether circulating S-glutathionylated cMyBP-C would be a biomarker for DD. Methods and Results Humans, African Green monkeys, and mice had DD determined by echocardiography. Blood samples were acquired and analyzed for S-glutathionylated cMyBP-C by immunoprecipitation. Circulating S-glutathionylated cMyBP-C in human participants with DD (n=24) was elevated (1.46±0.13-fold, =0.014) when compared with the non-DD controls (n=13). Similarly, circulating S-glutathionylated cMyBP-C was upregulated by 2.13±0.47-fold (=0.047) in DD monkeys (n=6), and by 1.49 (1.22-2.06)-fold (=0.031) in DD mice (n=5) compared with the respective non-DD controls. Circulating S-glutathionylated cMyBP-C was positively correlated with DD in humans. Conclusions Circulating S-glutathionylated cMyBP-C was elevated in humans, monkeys, and mice with DD. S-glutathionylated cMyBP-C may represent a novel biomarker for the presence of DD.

摘要

背景 cMyBP-C（心肌肌球蛋白结合蛋白-C）调节心肌收缩和舒张。先前，我们证明心肌 cMyBP-C 的 S-谷胱甘肽化水平升高与动物模型中的舒张功能障碍（DD）相关。在这项研究中，我们测试了循环 S-谷胱甘肽化 cMyBP-C 是否可作为 DD 的生物标志物。

方法和结果 通过超声心动图确定人类、非洲绿猴和小鼠的 DD。采集血液样本并通过免疫沉淀分析 S-谷胱甘肽化 cMyBP-C。与非 DD 对照组（n=13）相比，DD 患者（n=24）的循环 S-谷胱甘肽化 cMyBP-C 升高（1.46±0.13 倍，=0.014）。同样，DD 猴子（n=6）的循环 S-谷胱甘肽化 cMyBP-C 上调 2.13±0.47 倍（=0.047），DD 小鼠（n=5）上调 1.49（1.22-2.06）倍（=0.031）与各自的非 DD 对照组相比。循环 S-谷胱甘肽化 cMyBP-C 与人类的 DD 呈正相关。

结论 循环 S-谷胱甘肽化 cMyBP-C 在 DD 患者、猴子和小鼠中升高。S-谷胱甘肽化 cMyBP-C 可能代表 DD 存在的新型生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed7/9238749/8442c964d0a8/JAH3-11-e025295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed7/9238749/8fc1578e6a3e/JAH3-11-e025295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed7/9238749/8442c964d0a8/JAH3-11-e025295-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed7/9238749/8fc1578e6a3e/JAH3-11-e025295-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2ed7/9238749/8442c964d0a8/JAH3-11-e025295-g001.jpg

相似文献

1
Circulating S-Glutathionylated cMyBP-C as a Biomarker for Cardiac Diastolic Dysfunction.循环 S-谷胱甘肽化 cMyBP-C 作为心脏舒张功能障碍的生物标志物。
J Am Heart Assoc. 2022 Jun 7;11(11):e025295. doi: 10.1161/JAHA.122.025295. Epub 2022 Jun 3.
2
Phosphorylation of cardiac Myosin-binding protein-C is a critical mediator of diastolic function.心肌肌球蛋白结合蛋白-C的磷酸化是舒张功能的关键调节因子。
Circ Heart Fail. 2015 May;8(3):582-94. doi: 10.1161/CIRCHEARTFAILURE.114.001550. Epub 2015 Mar 4.
3
Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation.肌球蛋白结合蛋白C对体内左心室[校正]收缩/舒张动力学的控制：蛋白激酶A磷酸化依赖性和非依赖性调节。
Circulation. 2007 Nov 20;116(21):2399-408. doi: 10.1161/CIRCULATIONAHA.107.706523. Epub 2007 Nov 5.
4
Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function.蛋白激酶A使心肌肌球蛋白结合蛋白C磷酸化从而加速横桥动力学，调节心脏功能。
Circ Res. 2008 Oct 24;103(9):974-82. doi: 10.1161/CIRCRESAHA.108.177683. Epub 2008 Sep 18.
5
Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.心肌肌球蛋白结合蛋白 C 是心肌梗死的潜在诊断生物标志物。
J Mol Cell Cardiol. 2012 Jan;52(1):154-64. doi: 10.1016/j.yjmcc.2011.09.011. Epub 2011 Sep 19.
6
Point mutations in the tri-helix bundle of the M-domain of cardiac myosin binding protein-C influence systolic duration and delay cardiac relaxation.M 结构域肌球蛋白结合蛋白 C 的三聚体螺旋束中的点突变影响收缩持续时间并延迟心脏舒张。
J Mol Cell Cardiol. 2018 Jun;119:116-124. doi: 10.1016/j.yjmcc.2018.05.001. Epub 2018 May 3.
7
Cardiac myosin-binding protein-C is a critical mediator of diastolic function.心肌肌球蛋白结合蛋白 C 是舒张功能的关键介质。
Pflugers Arch. 2014 Mar;466(3):451-7. doi: 10.1007/s00424-014-1442-1. Epub 2014 Jan 19.
8
Differential roles of cardiac myosin-binding protein C and cardiac troponin I in the myofibrillar force responses to protein kinase A phosphorylation.心肌肌球蛋白结合蛋白C和心肌肌钙蛋白I在肌原纤维对蛋白激酶A磷酸化的力反应中的不同作用。
Circ Res. 2007 Aug 31;101(5):503-11. doi: 10.1161/CIRCRESAHA.107.153650. Epub 2007 Jul 19.
9
Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin.肌球蛋白结合蛋白-C 磷酸化调节肌球蛋白的超松弛状态。
Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11731-11736. doi: 10.1073/pnas.1821660116. Epub 2019 May 29.
10
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function.丝氨酸 282 在心肌肌球蛋白结合蛋白 C 磷酸化和心脏功能中的关键作用。
Circ Res. 2011 Jul 8;109(2):141-50. doi: 10.1161/CIRCRESAHA.111.242560. Epub 2011 May 19.

引用本文的文献

1
Cardiac TRPM7 Causes Diabetic Heart Failure With Preserved Ejection Fraction.心脏TRPM7导致射血分数保留的糖尿病性心力衰竭。
JACC Basic Transl Sci. 2025 Aug;10(8):101321. doi: 10.1016/j.jacbts.2025.101321.
2
The Role of Cardiac Troponin and Other Emerging Biomarkers Among Athletes and Beyond: Underlying Mechanisms, Differential Diagnosis, and Guide for Interpretation.心肌肌钙蛋白及其他新兴生物标志物在运动员及其他人群中的作用：潜在机制、鉴别诊断及解读指南
Biomolecules. 2024 Dec 19;14(12):1630. doi: 10.3390/biom14121630.
3
The Role of S-Glutathionylation in Health and Disease: A Bird's Eye View.

本文引用的文献

1
Cellular and molecular pathobiology of heart failure with preserved ejection fraction.射血分数保留的心力衰竭的细胞和分子病理生物学。
Nat Rev Cardiol. 2021 Jun;18(6):400-423. doi: 10.1038/s41569-020-00480-6. Epub 2021 Jan 11.
2
Magnesium supplementation improves diabetic mitochondrial and cardiac diastolic function.补充镁可改善糖尿病患者的线粒体功能和心脏舒张功能。
JCI Insight. 2019 Jan 10;4(1):e123182. doi: 10.1172/jci.insight.123182.
3
Mechanisms, diagnosis, and treatment of heart failure with preserved ejection fraction and diastolic dysfunction.
S-谷胱甘肽化在健康和疾病中的作用：鸟瞰。
Nutrients. 2024 Aug 18;16(16):2753. doi: 10.3390/nu16162753.
4
Bringing into focus the central domains C3-C6 of myosin binding protein C.聚焦肌球蛋白结合蛋白C的中心结构域C3-C6。
Front Physiol. 2024 Feb 29;15:1370539. doi: 10.3389/fphys.2024.1370539. eCollection 2024.
5
Implications of S-glutathionylation of sarcomere proteins in cardiac disorders, therapies, and diagnosis.肌节蛋白S-谷胱甘肽化在心脏疾病、治疗及诊断中的意义
Front Cardiovasc Med. 2023 Jan 24;9:1060716. doi: 10.3389/fcvm.2022.1060716. eCollection 2022.
射血分数保留型心力衰竭及舒张功能障碍的机制、诊断与治疗
Expert Rev Cardiovasc Ther. 2018 Aug;16(8):579-589. doi: 10.1080/14779072.2018.1497485. Epub 2018 Jul 16.
4
Epidemiology of Left Ventricular Systolic Dysfunction and Heart Failure in the Framingham Study: An Echocardiographic Study Over 3 Decades.弗雷明汉研究中心左心室收缩功能障碍和心力衰竭的流行病学：一项跨越 3 个十年的超声心动图研究。
JACC Cardiovasc Imaging. 2018 Jan;11(1):1-11. doi: 10.1016/j.jcmg.2017.08.007. Epub 2017 Oct 5.
5
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC.2016欧洲心脏病学会急性和慢性心力衰竭诊断与治疗指南：欧洲心脏病学会（ESC）急性和慢性心力衰竭诊断与治疗工作组编写，欧洲心脏病学会心力衰竭协会（HFA）提供特别贡献。
Eur Heart J. 2016 Jul 14;37(27):2129-2200. doi: 10.1093/eurheartj/ehw128. Epub 2016 May 20.
6
Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction.线粒体氧化应激在葡萄糖耐量、胰岛素抵抗和心脏舒张功能障碍中的作用
J Am Heart Assoc. 2016 May 5;5(5):e003046. doi: 10.1161/JAHA.115.003046.
7
Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium.心肌肌球蛋白结合蛋白C调节哺乳动物心肌的收缩速率和力量。
Circ Res. 2015 Jan 2;116(1):183-92. doi: 10.1161/CIRCRESAHA.116.300561.
8
Spironolactone for heart failure with preserved ejection fraction.
N Engl J Med. 2014 Jul 10;371(2):181-2. doi: 10.1056/NEJMc1405715.
9
Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties.四氢生物蝶呤通过逆转肌丝特性的变化改善舒张功能障碍。
J Mol Cell Cardiol. 2013 Mar;56:44-54. doi: 10.1016/j.yjmcc.2012.12.003. Epub 2012 Dec 14.
10
Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice.肌球蛋白结合蛋白 C3 基因突变杂合 knock-in 小鼠早期出现肌丝 Ca2+ 敏感性增加和舒张功能障碍。
J Mol Cell Cardiol. 2012 Jun;52(6):1299-307. doi: 10.1016/j.yjmcc.2012.03.009. Epub 2012 Mar 23.