Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials, Ministry of Education, Anhui University, Hefei, 230601, P. R. China.
Angew Chem Int Ed Engl. 2022 Aug 1;61(31):e202206755. doi: 10.1002/anie.202206755. Epub 2022 Jun 21.
The fabrication of high-order multiphoton excited fluorescent materials for second near-infrared (NIR-II, 1000-1700 nm) light-induced fluorescence imaging has always been an intractable challenge. In this study, a reasonable strategy guided by theoretical calculations was employed to fabricate a novel high-order multiphoton excited fluorescence (H-MPEF)-responsive UiO-type metal-organic framework (MOF, ZrTc). Strategically, the functionalization of the photonic-responsive thiazolothiazole-based organic ligand gave rise to amplified H-MPEF (four-photon activity) performance and prolonged excitation wavelength (1550 nm) of ZrTcI. The results reveal that the extended π-electron system, enhanced charge transfer, improved dipole moment, and weakened π-π stacking interactions within the MOFs endow them with excellent H-MPEF performance for NIR-II light-induced fluorescence imaging. It is an extremely rare report on H-MPEF bioimaging using MOFs and provide a universal strategy for the fabrication of H-MPEF-responsive materials.
用于二次近红外（NIR-II，1000-1700nm）光诱导荧光成像的高阶多光子激发荧光材料的制备一直是一个棘手的挑战。在这项研究中，我们采用了一种由理论计算指导的合理策略，来制备一种新型的高阶多光子激发荧光（H-MPEF）响应型 UiO 型金属有机骨架（MOF，ZrTc）。策略上，光子响应噻唑并噻唑基有机配体的功能化导致放大的 H-MPEF（四光子活性）性能和延长的激发波长（1550nm）的 ZrTcI。结果表明，扩展的π电子体系、增强的电荷转移、改善的偶极矩以及 MOFs 内减弱的π-π堆积相互作用赋予它们用于 NIR-II 光诱导荧光成像的优异 H-MPEF 性能。这是 MOFs 用于 H-MPEF 生物成像的极其罕见的报道，并为 H-MPEF 响应材料的制备提供了一种通用策略。
