Dramatically Enhancing Multiphoton Harvesting Metal-Organic Frameworks for NIR-II Photocatalysis through Functional Regulation of Octupolar Molecules.

The development of effective multiphoton absorption (MPA) materials for near-infrared (NIR) light-driven photocatalysis holds great significance. In this study, we incorporated two multibranched cyclometallated iridium(III) modules with varying degrees of conjugation onto MPA-inert metal-organic frameworks (MOFs) to active MPA performance. Subsequently, the MOFs were further modified with Co(II) and hyaluronic acid (HA) to fabricate and , respectively. By introducing octupolar molecules and expanding the conjugation, exhibited a larger MPA cross section for efficient NIR light absorption and improved carrier transfer, leading to outstanding NIR light-driven multiphoton photocatalytic hydrogen production. Moreover, the HA modification enabled to achieve specific multiphoton photocatalytic hydrogen therapy for cancer cells. This study provides valuable insights into constructing highly active MPA materials for NIR light-driven photocatalysis, presenting a potential platform for hydrogen therapy in tumor treatment.