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利用金属-有机框架实现近红外二区光驱动多光子光催化水分解用于氢气治疗。

Harnessing Metal-Organic Frameworks for NIR-II Light-Driven Multiphoton Photocatalytic Water Splitting in Hydrogen Therapy.

机构信息

Institutes of Physical Science and Information Technology, Faculty of Materials Science and Engineering, School of Chemistry and Chemical Engineering, School of Life Sciences, Key Laboratory of Structure and Functional Regulation of Hybrid Materials, Ministry of Education, Anhui University, Hefei, 230601, P. R. China.

出版信息

Adv Sci (Weinh). 2024 Oct;11(38):e2405643. doi: 10.1002/advs.202405643. Epub 2024 Aug 9.

Abstract

The construction of near-infrared (NIR) light-activated hydrogen-producing materials that enable the controlled generation and high-concentration release of hydrogen molecules in deep tumor tissues and enhance the effects of hydrogen therapy holds significant scientific importance. To address the key technical challenge of low-efficiency oxidation-reduction reactions for narrow-bandgap photocatalytic materials, this work proposes an innovative approach for the controllable fabrication of multiphoton photocatalytic materials to overcome the limitations imposed by traditional near-infrared photocatalysts with "narrow-bandgap" constraints. Herein, an NIR-responsive multiphoton photocatalyst, ZrTc-Co, is developed by utilizing a post-synthetic coordination modification strategy to introduce hydrogenation active site Co into a multiphoton responsive MOF (ZrTc). The results reveal that with the introduction of the Co site, electron-hole recombination can be efficiently suppressed, thus promoting the efficiency of hydrogen evolution reaction. In addition, the integration of Co can effectively enhance charge transfer and improve static hyperpolarizability, which endows ZrTc-Co with excellent multiphoton absorption. Moreover, hyaluronic acid modification endows ZrTc-Co with cancer cell-specific targeting characteristics, laying the foundation for tumor-specific elimination. Collectively, the proposed findings present a strategy for constructing NIR-II light-mediated hydrogen therapeutic agents for deep tumor elimination.

摘要

构建近红外(NIR)光激活产氢材料,能够在深部肿瘤组织中控制地产生和高浓度释放氢分子,并增强氢疗的效果,具有重要的科学意义。为了解决窄带隙光催化材料氧化还原反应效率低的关键技术挑战,本工作提出了一种用于可控制备多光子光催化材料的创新方法,以克服传统近红外光催化剂“窄带隙”限制所带来的限制。在此,通过后合成配位修饰策略,利用多光子响应 MOF(ZrTc)引入氢化活性位 Co,开发出一种对近红外光响应的多光子光催化剂 ZrTc-Co。结果表明,通过引入 Co 位,可以有效地抑制电子-空穴复合,从而提高产氢反应的效率。此外,Co 的引入可以有效地促进电荷转移并提高静态超极化率,使 ZrTc-Co 具有优异的多光子吸收能力。此外,透明质酸修饰赋予 ZrTc-Co 具有癌细胞特异性靶向的特性,为肿瘤特异性消除奠定了基础。总之,本研究提出了一种构建用于深部肿瘤消除的 NIR-II 光介导氢治疗剂的策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/423a/11481200/6cfe2a4a12d2/ADVS-11-2405643-g006.jpg

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