Department of Neurology, Faculty of Medicine, School of Medicine, Çukurova University, Sarıçam-Adana, 01330, Adana, Turkey.
Acta Neurol Belg. 2023 Aug;123(4):1257-1266. doi: 10.1007/s13760-022-01981-6. Epub 2022 Jun 3.
To determine the rate of non-convulsive status epilepticus with/without prominent motor phenomena (SE-PM/ NCSE) and predictive value of electroclinical findings of continious electroencephalography (cEEG) monitoring of these patients and its association with prognosis in intensive care units (ICU).
We retrospectively collected data of 218 patients whose cEEG was performed in ICU between 2016 and 2018. The cEEG for NCSE diagnosis was evaluated according to Salzburg Consensus Criteria (SCC).
The mean age of patients was 57.09 ± 18.9 (16-95) years and 49.1% (107) were female. Of 218 patients, 32 (14.7%) had SE-PM/NCSE. According to SCC the rate of NCSE (NCSE + possible NCSE) was 9.6% (n = 21). Prior to cEEG recording, 38.9% (n = 85) of overall patients had a history of seizure/convulsion, and 22.7% (n = 21) of these patients diagnosed with NCSE based on cEEG. The mortality rates in critically ill patients were 41.3% (30.8%, 42.8%; for SE-PM and NCSE respectively). Prognosis was associated with age, epilepsy diagnosis, having convulsion/seizure history on follow-up, GCS, need for ventilation, kind of drugs, sepsis diagnosis, and minimum frequency of background activity of the cEEG (p = 0.001, 0.002, 0.001, 0.020, 0.001, 0.001, 0.001, 0.0001 respectively).
NCSE findings are mostly found in patients who were comatose and had seizure/convulsion history on follow-up. Mortality is higher in patients diagnosed with NCSE followed in the ICU compared to SE-PM.
确定伴有/不伴有明显运动现象的非惊厥性癫痫持续状态（NCSE-PM/NCSE）的发生率，以及这些患者连续脑电图（cEEG）监测的临床电表现的预测价值及其与重症监护病房（ICU）预后的关系。
我们回顾性收集了 2016 年至 2018 年间在 ICU 进行 cEEG 的 218 例患者的数据。根据萨尔茨堡共识标准（SCC）评估 NCSE 的 cEEG 诊断。
患者的平均年龄为 57.09±18.9（16-95）岁，49.1%（107）为女性。218 例患者中，32 例（14.7%）存在 SE-PM/NCSE。根据 SCC，NCSE（NCSE+可能的 NCSE）的发生率为 9.6%（n=21）。在进行 cEEG 记录之前，85%（n=85）的患者有癫痫发作/抽搐史，其中 22.7%（n=21）根据 cEEG 诊断为 NCSE。危重症患者的死亡率为 41.3%（30.8%，42.8%；SE-PM 和 NCSE 分别）。预后与年龄、癫痫诊断、随访时有无抽搐/癫痫发作史、GCS、通气需求、药物种类、脓毒症诊断和 cEEG 背景活动最低频率有关（p=0.001、0.002、0.001、0.020、0.001、0.001、0.001、0.0001）。
NCSE 发现主要发生在昏迷且随访时有抽搐/癫痫发作史的患者中。与 SE-PM 相比，在 ICU 中诊断为 NCSE 的患者死亡率更高。
