Smith Lloyd M
Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Methods Mol Biol. 2022;2500:1-4. doi: 10.1007/978-1-0716-2325-1_1.
The Human Proteoform Project is an ambitious international effort to accelerate the development of technologies for proteoform analysis and to establish comprehensive atlases of proteoforms for humans and model organisms. Proteoforms are the ultimate molecular effectors of function in biology and are thus central to understanding that function. Proteoform analysis as it is practiced today is almost exclusively accomplished by mass spectrometry (MS) and is rapidly advancing in its capabilities. This volume presents a beautiful snapshot of emerging technologies at the exciting frontier of MS-based proteoform analysis.
人类蛋白质变体计划是一项雄心勃勃的国际努力，旨在加速蛋白质变体分析技术的开发，并建立人类和模式生物的蛋白质变体综合图谱。蛋白质变体是生物学中功能的最终分子效应器，因此对于理解该功能至关重要。当今实践中的蛋白质变体分析几乎完全通过质谱（MS）完成，并且其能力正在迅速提升。本书展示了基于质谱的蛋白质变体分析这一令人兴奋的前沿领域中新兴技术的精彩概况。
