Habeck J O, Kreher C, Huckstorf C, Behm R
Anat Anz. 1987;163(1):49-55.
The carotid bodies of renal hypertensive rats (one kidney wrap model) were studied by light-microscopic and morphometric methods. Rats with established hypertension showed massive intraglomic vascular alterations, such as exudation of plasma, subendothelial fibrinoid deposits and fibrinoid necroses of the intima and media. Additionally a granuloma-like perivascular proliferation of fibroblasts and histiocytes was seen. The total carotid body volume was enlarged but the volume of the specific glomic tissue was reduced in comparison with normotensive controls. In rats with borderline hypertension similar pathological changes were found but in a more reduced extension. Additionally in these rats some intraglomic vessels showed an accumulation of acid mucopolysaccharides and an hyperplasia of mediocytes. Rats with such vessel alterations also exhibited a small enlargement of specific glomic tissue. In general the pathological changes of the carotid bodies in renal hypertensive rats are different in comparison with those in the glomera carotici of rats with spontaneous hypertension (SHR, GH rats). This study suggests that an elevated blood pressure does not solely cause an increment of the specific chemoreceptive tissue mass of the carotid bodies.
采用光学显微镜和形态测量学方法对肾性高血压大鼠（单肾包囊模型）的颈动脉体进行了研究。已患高血压的大鼠出现了肾小球内大量血管改变，如血浆渗出、内皮下纤维蛋白样沉积物以及内膜和中膜的纤维蛋白样坏死。此外，还可见到成纤维细胞和组织细胞的肉芽肿样血管周围增殖。与正常血压对照组相比，颈动脉体总体积增大，但特定肾小球组织的体积减小。在临界高血压大鼠中发现了类似的病理变化，但范围较小。此外，在这些大鼠中，一些肾小球内血管显示酸性粘多糖积聚和中膜细胞增生。有此类血管改变的大鼠还表现出特定肾小球组织略有增大。一般而言，肾性高血压大鼠颈动脉体的病理变化与自发性高血压大鼠（SHR、GH大鼠）颈动脉体的病理变化不同。本研究表明，血压升高并非单纯导致颈动脉体特定化学感受组织质量增加。
