Habeck J O, Huckstorf C
Institute of Pathology, Bezirkskrankenhaus, Friedrich Wolf, GDR, Karl-Marx-Stadt.
Biomed Biochim Acta. 1987;46(12):915-7.
The influence of a chronic blood pressure lowering on carotid body morphology and volume was studied in spontaneously hypertensive rats (SHR). Oral propranolol, a beta-adrenergic blocking agent, was administered beginning 3 weeks after conception up to 18 weeks of the litters. At the end of the experiment the blood pressure was significantly lower in the treated animals. These rats exhibited fewer vascular alterations in their carotid bodies. The carotid body volumes and the relationship of glomic cells, the blood vessels including endothelial cells, and the connective tissue in the carotid bodies did not differ between treated and non-treated rats. It can be concluded that long-term blood pressure lowering by propranolol in SHR does not influence carotid body volume increase.
在自发性高血压大鼠（SHR）中研究了慢性血压降低对颈动脉体形态和体积的影响。从怀孕后3周开始直至幼崽18周龄，口服β-肾上腺素能阻滞剂普萘洛尔。实验结束时，治疗组动物的血压显著降低。这些大鼠的颈动脉体血管改变较少。治疗组和未治疗组大鼠的颈动脉体体积以及颈动脉体中球细胞、包括内皮细胞的血管和结缔组织之间的关系并无差异。可以得出结论，普萘洛尔对SHR进行长期降压不会影响颈动脉体体积增加。
