School of Public Health, College of Health Sciences and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.
PLoS One. 2022 Jun 3;17(6):e0269473. doi: 10.1371/journal.pone.0269473. eCollection 2022.
The objective of this study was to identify determinants of syphilis infection among pregnant women attending antenatal care in hospitals in the Wolaita zone, Southern Ethiopia,2020.
An unmatched facility-based case-control study was conducted among pregnant women who received antenatal care at four randomly selected hospitals from September 1 to October 30, 2020. A two-stage sampling technique was used in the selection of hospitals and study participants. The data were collected from the participants using a pre-tested structured questionnaire and analyzed using STATA Release 15. Bivariate and multivariate logistic regression analyses were used to determine syphilis infection determinants. Crude and adjusted odds ratios were used for each explanatory variable with a 95% confidence level. A statistically significant association was declared when a p-value was less than 0.05.
A total of 296 (74 cases and 222 controls) pregnant women participated, with a recruitment rate of 97.4%. In multivariate logistic regression, the likelihood of developing a maternal syphilis infection was higher in pregnant women who had more than one-lifetime sexual partner [AOR = 3.59, 95% CI (1.09-11.71)]; a history of sexually transmitted infections [AOR = 3.46, 95%CI (1.32-9.08)] and used a substance [AOR = 3.39, 95%CI (1.31-8.77)].
Sexual-related factors continued to be a major determinant of syphilis in pregnant women. The results suggest that there is a need to promote safe sexual behavior, raise awareness about the risk of STIs, and early diagnosis and treatment of STIs to control syphilis infection, and necessary to make the antenatal care service comprehensive for pregnant women.
本研究旨在确定埃塞俄比亚南部沃莱塔地区医院接受产前护理的孕妇中梅毒感染的决定因素，2020 年。
2020 年 9 月 1 日至 10 月 30 日，在随机选择的四家医院接受产前护理的孕妇中进行了一项非匹配的基于机构的病例对照研究。采用两阶段抽样技术选择医院和研究参与者。使用经过预测试的结构化问卷从参与者那里收集数据，并使用 STATA 版本 15 进行分析。使用二变量和多变量逻辑回归分析确定梅毒感染决定因素。使用每个解释变量的粗比和调整比值比，并使用 95%置信水平。当 p 值小于 0.05 时，宣布存在统计学显著关联。
共有 296 名（74 例病例和 222 例对照）孕妇参与，招募率为 97.4%。在多变量逻辑回归中，具有多个性伴侣的孕妇发生孕产妇梅毒感染的可能性更高 [AOR = 3.59，95%CI（1.09-11.71）]；有性传播感染史 [AOR = 3.46，95%CI（1.32-9.08）] 和使用物质 [AOR = 3.39，95%CI（1.31-8.77）]。
与性相关的因素仍然是孕妇梅毒的主要决定因素。结果表明，需要促进安全性行为，提高对性传播感染风险的认识，并早期诊断和治疗性传播感染，以控制梅毒感染，有必要为孕妇提供全面的产前保健服务。
