Hakizimana Theoneste, Muhumuza Joy, Selamo Fabrice Molen, Ishimwe Marie Pascaline Sabine, Kajabwangu Rogers, Jelle Osman Mohamud, Muhumuza Joshua, Kiyaka Sonye Magugu, Nyakato Sandra, Fajardo Yarine
Department of Obstetrics and Gynecology, Kampala International University, Western Campus, Uganda.
Department of Surgery, Kampala International University, Western Campus, Uganda.
Int J Reprod Med. 2023 Aug 24;2023:2971065. doi: 10.1155/2023/2971065. eCollection 2023.
Early prenatal syphilis testing and treatment are essential preventative measures for maternal syphilis and associated adverse pregnancy outcomes of pregnancy; however, data shows that two-thirds of all cases are missed among women who visit prenatal care center at least once but are not tested for syphilis. This study determined the prevalence and factors associated with syphilis infection among mothers with missed opportunities for antenatal syphilis testing in rural western Uganda delivered at Fort Portal Regional Referral Hospital (FRRH).
A cross-sectional study was done during the period from April 2022 to June 2022. A total of 124 participants had been recruited consecutively from postnatal ward of FRRH. Pretested questionnaires were used to obtain information on data required for analysis. Venous blood sampling (2 ml taken from the forearm using anticoagulant free vacutainer) was done for all mothers who missed opportunity for prenatal syphilis testing using both RPR and TPHA. Descriptive statistics followed by binary logistic regression analysis was done using SPSS version 22.0.
The prevalence of syphilis infection was 27 (21.8%). After adjusted analysis, having more than one sexual partners in the past one year was associated with higher odds of syphilis infection (aOR = 24.922, 95% CI: 4.462-139.201, < 0.001), and staying with the partner was found to be associated with lower odds of syphilis infection (aOR = 0.213, 95% CI: 0.040-1.142, = 0.050).
The study identified high prevalence of syphilis infection among mothers with missed opportunities for antenatal syphilis testing, and this was positively associated with having more than one sexual partners in the past one year and negatively associated with not staying with partner.
早期产前梅毒检测和治疗是预防孕产妇梅毒及相关不良妊娠结局的重要措施；然而，数据显示，在至少去过一次产前保健中心但未进行梅毒检测的女性中，三分之二的病例被漏诊。本研究确定了在乌干达西部农村地区福特portal地区转诊医院（FRRH）分娩的、错过产前梅毒检测机会的母亲中梅毒感染的患病率及相关因素。
于2022年4月至2022年6月期间进行了一项横断面研究。从FRRH产后病房连续招募了124名参与者。使用预先测试的问卷获取分析所需的数据信息。对所有错过产前梅毒检测机会的母亲进行静脉血采样（使用不含抗凝剂的真空采血管从前臂采集2毫升血液），采用快速血浆反应素环状卡片试验（RPR）和梅毒螺旋体血凝试验（TPHA）进行检测。使用SPSS 22.0软件进行描述性统计，随后进行二元逻辑回归分析。
梅毒感染患病率为27例（21.8%）。经过校正分析，过去一年有多个性伴侣与梅毒感染几率较高相关（调整后的比值比[aOR]=24.922，95%置信区间[CI]：4.462 - 139.201，P<0.001），而与伴侣同住与梅毒感染几率较低相关（aOR = 0.213，95% CI：0.040 - 1.142，P = 0.050）。
该研究发现，错过产前梅毒检测机会的母亲中梅毒感染患病率较高，这与过去一年有多个性伴侣呈正相关，与未与伴侣同住呈负相关。
