生物钟免疫系统。
The circadian immune system.
机构信息
Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Biomedical Center (BMC), Institute for Cardiovascular Physiology and Pathophysiology, Walter Brendel Center for Experimental Medicine (WBex), Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.
出版信息
Sci Immunol. 2022 Jun 3;7(72):eabm2465. doi: 10.1126/sciimmunol.abm2465.
The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were the first to identify immune responses to be under a circadian control. Only in the last decade, however, have the molecular factors governing circadian immune rhythms been identified. These studies have revealed a highly complex picture of the interconnectivity of rhythmicity within immune cells with that of their environment. Here, we provide a global overview of the circadian immune system, focusing on recent advances in the rapidly expanding field of circadian immunology.
免疫系统具有很强的时间依赖性。20 世纪 60 年代的开创性研究首次发现，免疫反应受昼夜节律控制。然而，直到最近十年，调控昼夜节律免疫节律的分子因素才被确定。这些研究揭示了免疫细胞内部的节律性与它们所处环境之间高度复杂的互联关系。在这里，我们提供了对生物钟免疫系统的全面概述，重点介绍了在快速发展的生物钟免疫学领域的最新进展。
Zotero 插件