尿液外泌体：泌尿系统疾病治疗的新兴递药工具和生物标志物。
Urinary exosomes: Emerging therapy delivery tools and biomarkers for urinary system diseases.
机构信息
Departments of Infectious Disease, First Affiliated Hospital of China Medical University, Shenyang, China.
Departments of Geriatrics, First Affiliated Hospital of China Medical University, Shenyang, China.
出版信息
Biomed Pharmacother. 2022 Jun;150:113055. doi: 10.1016/j.biopha.2022.113055. Epub 2022 Apr 30.
Urinary exosomes (UE) are small circular membranous vesicles with a lipid bilayer with a diameter of 40-160 nm secreted by epithelial cells of the kidney and genitourinary system, which can reflect the physiological and functional status of secretory cells. Protein and RNA in exosomes can be used as markers for diseases diagnosis. Urine specimens are available and non-invasive. The protein and RNA in UE are more stable than the soluble protein and RNA in urine, which have broad application prospects in the diagnosis of urinary system diseases. This article reviews the recent advances in the application of protein or RNA in UE as markers to the diagnosis of urinary system diseases.
尿外泌体（UE）是直径为 40-160nm 的由肾脏和泌尿生殖系统上皮细胞分泌的具有双层脂膜的小型环状膜囊泡，可反映分泌细胞的生理和功能状态。外泌体中的蛋白质和 RNA 可作为疾病诊断的标志物。尿液标本易得且无创。UE 中的蛋白质和 RNA 比尿液中的可溶性蛋白质和 RNA 更稳定，在泌尿系统疾病的诊断中有广泛的应用前景。本文就 UE 中蛋白质或 RNA 标志物在泌尿系统疾病诊断中的应用进展作一综述。
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