School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650031, People's Republic of China.
Zhuhai Key Laboratory of Fundamental and Applied Research in Traditional Chinese Medicine, Zhuhai Campus of Zunyi Medical University, Zhuhai, Guangdong 519000, People's Republic of China.
J Nat Prod. 2022 Jun 24;85(6):1486-1494. doi: 10.1021/acs.jnatprod.1c01155. Epub 2022 Jun 6.
Cultivation of an endophytic fungus sp. KMU18029 with suberanilohydroxamic acid (SAHA), a histone deacetylase inhibitor, led to the isolation of two pairs of diterpenic meroterpenoids with a unique natural product framework combining features of pyripyropenes and decaturins/oxalicines, pyrandecarurins A () and B (), pileotin A () and B (), along with their potential precursor decaturenoid (). Compounds , , , and were new. The structures of - were elucidated by extensive spectroscopic analyses. The absolute configurations of - were determined by single-crystal X-ray diffraction, NOESY spectra, ECD calculations, and biogenetic considerations. The absolute configuration of compound was confirmed for the first time. Compound showed moderate activity against AChE with an IC value of 13.9 ± 1.1 μM.
内生真菌 sp. KMU18029 的培养物与组蛋白去乙酰化酶抑制剂 （SAHA） 一起，导致了两种二萜类混合萜类化合物的分离，它们具有独特的天然产物骨架，结合了吡喃吡咯烯和 decaturin/oxalicines 的特征，pyrandecarurins A () 和 B (), pileotin A () 和 B (), 以及它们的潜在前体 decaturenoid ()。化合物,,, 和 是新的。通过广泛的光谱分析阐明了 - 的结构。通过单晶 X 射线衍射、NOESY 光谱、ECD 计算和生物发生考虑确定了 - 的绝对构型。化合物 的绝对构型是首次确定的。化合物 对 AChE 表现出中等活性，IC 值为 13.9 ± 1.1 μM。
