Al-Amin Mohammad, Eltayeb Nagla Mustafa, Hossain Chowdhury Faiz, Rahiman Siti Sarah Fazalul, Khairuddean Melati, Muhamad Salhimi Salizawati
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, 11800 USM, Malaysia.
Tropical Medicine Research Institute (TMRI), National Centre for Research (NCR), 11111 Khartoum, Sudan.
J Asian Nat Prod Res. 2022 Jun 4:1-12. doi: 10.1080/10286020.2022.2081562.
Bioassay-guided separation afforded furanodienone 1,10-epoxide () as the new compound, curcolone ( as partially described compound and ten known compounds; germacrone (), furanodienone (, curzerenone ), curcumenol (), zederone (), comosone II (), (1E,4E,8R)-8-hydroxygermacra-1(10),4,7(11)-trieno-12,8-lactone (), 13-hydroxygermacrone (), curcuzederone () and demethoxycurcumin (). The study showed that germacrone, furanodienone, curzerenone, comosone II, 13-hydroxygermacrone, curcuzederone and demethoxycurcumin are the bioactive compounds of rhizomes. Comosone II significantly inhibited MDA-MB-231 cell migration and invasion through the inhibition of MMP-9 enzyme. The present study may lead to further anticancer studies of comosone II and supports the traditional uses of rhizomes.
生物活性导向分离得到了呋喃二烯酮1,10 - 环氧化物（）作为新化合物，莪术二酮（作为部分描述的化合物）以及十种已知化合物；吉马酮（）、呋喃二烯酮（）、莪术烯酮（）、莪术醇（）、姜黄酮（）、科莫松II（）、(1E,4E,8R)-8 - 羟基吉马-1(10),4,7(11)-三烯-12,8 - 内酯（）、13 - 羟基吉马酮（）、莪术姜黄酮（）和去甲氧基姜黄素（）。研究表明，吉马酮、呋喃二烯酮、莪术烯酮、科莫松II、13 - 羟基吉马酮、莪术姜黄酮和去甲氧基姜黄素是该根茎的生物活性化合物。科莫松II通过抑制MMP - 9酶显著抑制MDA - MB - 231细胞的迁移和侵袭。本研究可能会引发对科莫松II的进一步抗癌研究，并支持该根茎的传统用途。
