Department of Epidemiology and Health Statistics, School of Public Health and Management, Ningxia Medical University, Yinchuan, 750004, Ningxia Hui Autonomous Region, China.
Research Center of Health Big Data, Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, 750004, Ningxia Hui Autonomous Region, China.
BMC Endocr Disord. 2022 Jun 4;22(1):151. doi: 10.1186/s12902-022-01055-x.
The cognitive function of people with diabetes has gained an increasing interest in recent years, and this study focuses on exploring the relationship between undiagnosed diabetes and cognitive function among the middle-aged and elderly people in China.
The data came from the China Health and Retirement Longitudinal Study (CHARLS) which was conducted between July and October 2015. 9855 subjects were enrolled in the study. Executive function and episodic memory were used to assess cognitive function. The subjects were divided into three groups: no diabetes, diagnosed diabetes, and undiagnosed diabetes, and weighted multiple linear regression models were established to evaluate the association of undiagnosed diabetes with cognitive function.
After controlling for covariates, undiagnosed diabetes was statistically associated with executive function (β = -0.215, P < 0.01). In the age group of ≥65 years, undiagnosed diabetes was statistically associated with executive function (β = -0.358, P < 0.01) and episodic memory (β = -0.356, P < 0.01). When adjusting for confounders, no statistically significant associations were found between diagnosed diabetes and cognitive function except in 45-54 age group (β = 0.374, P < 0.05).
The cross-sectional study suggested that undiagnosed diabetes was linked to poor cognitive function, especially in the elderly population. Timely diagnosis and active treatment of diabetes are important to reduce the occurrence of cognitive impairment. Further prospective cohort studies are required to articulate the association between undiagnosed diabetes and cognitive function.
近年来，人们对糖尿病患者的认知功能越来越感兴趣，本研究旨在探讨中国中老年人中未确诊糖尿病与认知功能之间的关系。
数据来自于 2015 年 7 月至 10 月进行的中国健康与退休纵向研究（CHARLS）。共纳入 9855 名研究对象。采用执行功能和情景记忆评估认知功能。将研究对象分为三组：无糖尿病、已确诊糖尿病和未确诊糖尿病，并建立加权多重线性回归模型来评估未确诊糖尿病与认知功能的关系。
在控制了混杂因素后，未确诊糖尿病与执行功能呈统计学相关（β=-0.215，P<0.01）。在年龄≥65 岁的人群中，未确诊糖尿病与执行功能（β=-0.358，P<0.01）和情景记忆（β=-0.356，P<0.01）呈统计学相关。调整混杂因素后，除 45-54 岁年龄组外（β=0.374，P<0.05），已确诊糖尿病与认知功能之间无统计学显著相关性。
本横断面研究表明，未确诊糖尿病与认知功能下降有关，尤其是在老年人群中。及时诊断和积极治疗糖尿病对于降低认知障碍的发生非常重要。需要进一步开展前瞻性队列研究来阐明未确诊糖尿病与认知功能之间的关系。
