Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Department of Surgical Biotechnology, University College London, London, UK.
Trends Pharmacol Sci. 2022 Sep;43(9):709-711. doi: 10.1016/j.tips.2022.05.001. Epub 2022 May 31.
Achieving complete nanoparticle (NP) clearance is a key consideration in the design of safe and translatable nanomedicines. Renal-clearable nano formulations must encompass the beneficial nanoscale functionalities whilst exhibiting clearance profiles like those of small-molecule therapeutics. Recent developments in the field have enabled the growth of novel renal-clearable NPs with transformable sizes that take advantage of alternative clearance mechanisms to achieve controlled and efficient renal excretion to improve potential clinical translation.
实现完全的纳米颗粒 (NP) 清除是安全且可转化的纳米药物设计的关键考虑因素。肾脏可清除的纳米制剂必须包含有益的纳米级功能，同时表现出与小分子治疗剂相似的清除特征。该领域的最新进展使得具有可转换尺寸的新型肾脏可清除 NP 的生长成为可能，这些 NP 利用替代清除机制来实现可控和有效的肾脏排泄，以提高潜在的临床转化。
