Department of Obstetrics and Gynaecology, San Fernando General Hospital, South-West Regional Health Authority, San Fernando, Trinidad and Tobago.
Department of Pathology, Port of Spain General Hospital, North-West Regional Health Authority, San Fernando, Trinidad and Tobago.
World J Surg Oncol. 2022 Jun 3;20(1):177. doi: 10.1186/s12957-022-02648-5.
Poorly differentiated diffuse-type gastric adenocarcinoma often presents at an advanced stage. While gastric cancer typically metastasizes to the liver, lung and bone, metastasis to the uterine cervix is extremely rare. To our knowledge, less than forty cases have been described in the medical literature.
We report a case of a 47-year-old woman who presented to us with symptomatic uterine leiomyomas and subsequently underwent a successful total laparoscopic hysterectomy and bilateral salpingo-oophorectomy. The diagnosis of metastatic cancer involving the cervix was established incidentally on histopathology, which demonstrated atypical signet ring cells in the lymphovascular spaces of the cervix. Further investigations for a primary malignancy revealed a poorly differentiated diffuse-type gastric adenocarcinoma.
Gastric cancer involving the uterine cervix is rare and associated with a poor prognosis. When presented with isolated cervical metastases, the gastrointestinal tract should be considered as a possible primary source. Due to the limited publications on this clinical entity, we expect to raise awareness and study this unique manifestation of gastric cancer by presenting our case.
低分化弥漫型胃腺癌常处于晚期。胃癌通常转移至肝、肺和骨，而转移至子宫颈极其罕见。据我们所知，文献中仅报道了不到四十例。
我们报告了一例 47 岁女性，因有症状的子宫肌瘤就诊，随后成功进行了全腹腔镜子宫切除术和双侧输卵管卵巢切除术。宫颈转移癌的诊断是在组织病理学上偶然发现的，宫颈淋巴管内有非典型印戒细胞。进一步的原发性恶性肿瘤检查显示为低分化弥漫型胃腺癌。
胃腺癌累及子宫颈罕见，预后不良。当出现孤立性宫颈转移时，应考虑胃肠道作为可能的原发灶。由于对此临床实体的有限文献报道，我们希望通过报告我们的病例来提高对这种胃癌独特表现的认识并对此进行研究。
