Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.
Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, China.
Ageing Res Rev. 2022 Aug;79:101659. doi: 10.1016/j.arr.2022.101659. Epub 2022 Jun 2.
Frailty is a clinical geriatric syndrome characterized by decreased multisystem function and increased vulnerability to adverse outcomes. Although numerous studies have been conducted on frailty, the underlying mechanisms and management strategies remain unclear. As rodents share homology with humans, they are used extensively as animal models to study human diseases. Rodent frailty models can be classified broadly into the genetic modification and non-genetic modification models, the latter of which include frailty assessment models (based on the Fried frailty phenotype and frailty index methods) and induced frailty models. Such models were developed for use in investigating frailty-related physiological changes at the gene, cellular, molecular, and system levels, including the organ system level. Furthermore, exercise, diet, and medication interventions, in addition to their combinations, could improve frailty status in rodents. Rodent frailty models provide novel and effective tools for frailty research. In the present paper, we review research progress in rodent frailty models, mechanisms, and management, which could facilitate and guide further clinical research on frailty in older adults.
衰弱是一种以多系统功能下降和易发生不良结局为特征的临床老年综合征。尽管已经有大量关于衰弱的研究，但衰弱的潜在机制和管理策略仍不清楚。由于啮齿动物与人具有同源性，因此它们被广泛用作研究人类疾病的动物模型。啮齿动物衰弱模型可大致分为遗传修饰和非遗传修饰模型，后者包括衰弱评估模型（基于 Fried 衰弱表型和衰弱指数方法）和诱导衰弱模型。这些模型的开发是为了研究与衰弱相关的基因、细胞、分子和系统水平（包括器官系统水平）的生理变化。此外，运动、饮食和药物干预以及它们的组合可以改善啮齿动物的衰弱状态。啮齿动物衰弱模型为衰弱研究提供了新颖而有效的工具。本文综述了啮齿动物衰弱模型、机制和管理方面的研究进展，这将有助于并指导进一步对老年人衰弱的临床研究。
