State Key Laboratory of Pollution Control and Resources Reuse, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, PR China.
College of Chemistry and Environment Engineering, Yancheng Teachers University, Yancheng, Jiangsu Province 224002, PR China.
Sci Total Environ. 2022 Sep 10;838(Pt 4):156415. doi: 10.1016/j.scitotenv.2022.156415. Epub 2022 May 31.
The overuse and random discharge of antibiotics can cause serious environmental pollution. Sludge acts as a repository for antibiotics, its anaerobic fermentation process will inevitably be affected. This study investigated the effects of a typical antibiotic contaminant, sulfadiazine (SDZ), on the anaerobic fermentation of sludge for hydrogen production. Results demonstrated that the production of hydrogen was significantly inhibited by SDZ, and the inhibition was enhanced with increasing SDZ content. Within 5 days, the cumulative amount of hydrogen with 500 mg SDZ/kg dry sludge was 8.5 mL, which was only 32.2% of that in the control (26.4 mL). Mechanistic investigation showed that the reduced hydrogen production when SDZ existed was mainly attributed to the suppression of pyruvate decarboxylation during the hydrogen production stage, and the diversity of microorganisms, especially the abundance of microorganisms and the activities of key enzymes closely related to hydrogen production were inhibited with SDZ, resulting in less hydrogen accumulation.
抗生素的过度使用和随意排放会造成严重的环境污染。污泥作为抗生素的储存库，其厌氧发酵过程必然会受到影响。本研究探讨了一种典型的抗生素污染物磺胺嘧啶（SDZ）对污泥产氢的厌氧发酵的影响。结果表明，SDZ 显著抑制了氢气的产生，且随着 SDZ 含量的增加，抑制作用增强。在 5 天内，含 500mg SDZ/kg 干污泥的累积氢气量为 8.5mL，仅为对照组（26.4mL）的 32.2%。机理研究表明，当 SDZ 存在时，氢气产量降低主要归因于产氢阶段丙酮酸脱羧作用受到抑制，且 SDZ 抑制了微生物的多样性，特别是与产氢密切相关的微生物丰度和关键酶的活性，导致氢气积累减少。
