Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
Medical Administrative Department, Taichung Army Forces General Hospital, Taichung, Taiwan.
PLoS One. 2022 Mar 23;17(3):e0265629. doi: 10.1371/journal.pone.0265629. eCollection 2022.
Aging-related hypogonadism in men is related to the deterioration of overall health. Those with this disease rarely receive treatment. The hypertriglyceridemic waist (HTGW) phenotype is a tool for predicting abnormalities of cardiovascular metabolism. However, the relationship between the HTGW phenotype and hypogonadism remains undetermined. This study aimed to determine the association between HTGW phenotype and hypogonadism in different age groups.
Data of this cross-sectional study were obtained from MJ Health Screening Center in Taiwan from 2007 to 2016. The HTGW phenotype was divided into four categories based on whether the waist circumference (WC) and triglyceride levels were normal. WC of <90 cm and triglyceride level of <150 mg/dL were defined as normal. Hypogonadism was defined as a testosterone level of <300 ng/dL.
Overall, 6442 male participants were divided into three age groups: <50, 50-64, and ≥65 years (n = 4135, 1958, and 349; age groups 1, 2, and 3, respectively). The overall prevalence of hypogonadism was 10.6%. In group 1, participants with HTGW (odds ratio, 1.98; 95% confidence interval (CI), 1.354-2.896) had a higher risk of hypogonadism than those with normal WC and normal triglyceride levels after adjustment for body mass index and fasting blood glucose level. In group 2, participants with HTGW (odds ratio, 1.873; 95% CI, 1.099-3.193) had an increased risk of hypogonadism after adjustment for body mass index, fasting blood glucose level, Cholesterol levels, high-density lipoprotein (HDL) levels, low-density lipoprptein (LDL) levels and smoking status. However, no relationship was observed between HTGW phenotype and hypogonadism in group 3.
HTGW phenotype was highly associated with hypogonadism in Taiwanese adult men. More attention should be paid to men aged <50 years with HTGW.
男性与衰老相关的性腺功能减退与整体健康状况恶化有关。患有这种疾病的人很少接受治疗。高甘油三酯性腰围（HTGW）表型是预测心血管代谢异常的工具。然而，HTGW 表型与性腺功能减退之间的关系尚未确定。本研究旨在确定不同年龄组中 HTGW 表型与性腺功能减退之间的关系。
本横断面研究的数据来自台湾 MJ 健康筛查中心 2007 年至 2016 年的数据。根据腰围（WC）和甘油三酯水平是否正常，将 HTGW 表型分为四类。WC<90cm 和甘油三酯水平<150mg/dL 定义为正常。性腺功能减退定义为睾酮水平<300ng/dL。
总体而言，6442 名男性参与者被分为三组：<50 岁、50-64 岁和≥65 岁（n=4135、1958 和 349；年龄组 1、2 和 3）。性腺功能减退的总体患病率为 10.6%。在组 1 中，与 WC 和甘油三酯水平正常的参与者相比，HTGW 参与者（比值比，1.98；95%置信区间（CI），1.354-2.896）发生性腺功能减退的风险更高，调整体重指数和空腹血糖水平后。在组 2 中，与 HTGW 参与者（比值比，1.873；95%CI，1.099-3.193）相比，调整体重指数、空腹血糖水平、胆固醇水平、高密度脂蛋白（HDL）水平、低密度脂蛋白（LDL）水平和吸烟状态后，性腺功能减退的风险增加。然而，在组 3 中，HTGW 表型与性腺功能减退之间没有关系。
HTGW 表型与台湾成年男性性腺功能减退密切相关。应更加关注患有 HTGW 的<50 岁男性。
