Cellular Biology and Molecular Genetics Laboratory, Sciences Faculty, Ibn Zohr University, Morocco.
Medical Biology Unit, Provincial Hospital Hassan 1er, Tiznit, Morocco.
Rocz Panstw Zakl Hig. 2024 Aug 14;75(2):185-193. doi: 10.32394/rpzh/190852. Epub 2024 Jul 25.
The global prevalence of metabolic syndrome (MetS) increases susceptibility to non-communicable diseases such as obesity, type 2 diabetes, and cardiovascular disease, posing significant health risks. Effective prevention and management require objective tools. The hypertriglyceridemic waist (TG+WC+) phenotype is proposed as a less expensive approach to identify individuals with metabolic syndrome and other cardiovascular risk factors.
The current aim of this investigation is to study the epidemiological characteristics of the hypertriglyceridemic waist phenotype and their correlations with cardiovascular risk factors and MetS in the Moroccan Amazigh ethnic group from the Souss region of Morocco.
A total of 827 Amazigh adults from the Sousse region of Morocco were divided into four distinct phenotype groups: TG-WC-, TG+WC-, TG-WC+, and TG+WC+ (normal TG- or high TG+ triglycerides/normal WC- or high WC+ waist circumference). The association of the different phenotypes with MetS and other cardiovascular risk factors was established by logistic regression analysis.
The prevalence of the TG+WC+ phenotype was 27.7% and varied according to age group and sex. Among subjects with the TG+WC+ phenotype, most were 41-60 years old (53.3%) and in women (74.2%). Participants with the TG+WC+ phenotype had the highest prevalence of dyslipidemia (87.3%), hypoHDLaemia (69.9%), and general obesity (37.12%). The three phenotypes TG-WC-, TG+WC- and TG-WC+ were less associated with MetS and other cardiovascular risk factors. Moreover, people with the TG+WC+ phenotype had a very high odds ratio for MetS.
These findings suggest that the TG+WC+ phenotype exhibits a robust correlation with MetS and additional variables connected to cardiovascular risk. The TG+WC+ phenotype serves as a valuable clinical instrument for detecting individuals vulnerable to MetS and cardiovascular diseases.
代谢综合征（MetS）的全球患病率增加了肥胖、2 型糖尿病和心血管疾病等非传染性疾病的易感性，带来了重大的健康风险。有效的预防和管理需要客观的工具。高甘油三酯腰围（TG+WC+）表型被提出作为一种更经济的方法来识别代谢综合征和其他心血管危险因素的个体。
本研究旨在研究摩洛哥苏斯地区柏柏尔人高甘油三酯腰围表型的流行病学特征及其与心血管危险因素和代谢综合征的相关性。
共有 827 名来自摩洛哥苏斯地区的柏柏尔成年人分为四个不同的表型组：TG-WC-、TG+WC-、TG-WC+和 TG+WC+（正常 TG-或高 TG+甘油三酯/正常 WC-或高 WC+腰围）。通过逻辑回归分析确定不同表型与代谢综合征和其他心血管危险因素的关系。
TG+WC+表型的患病率为 27.7%，并根据年龄组和性别而有所不同。在 TG+WC+表型的受试者中，大多数年龄在 41-60 岁（53.3%）和女性（74.2%）。具有 TG+WC+表型的参与者具有最高的血脂异常（87.3%）、低 HDLa 血症（69.9%）和一般肥胖（37.12%）患病率。TG-WC-、TG+WC-和 TG-WC+三种表型与代谢综合征和其他心血管危险因素的相关性较低。此外，具有 TG+WC+表型的人患代谢综合征的可能性非常高。
这些发现表明，TG+WC+表型与代谢综合征和与心血管风险相关的其他变量密切相关。TG+WC+表型是一种有价值的临床工具，可用于检测易患代谢综合征和心血管疾病的个体。
