Department of Cardiology, University of Leipzig, Liebigstraße 20, 04103, Leipzig, Germany.
Department of Cardiology, Kath. St. Paulus Gesellschaft, St-Marien-Hospital Lünen, Altstadtstrasse 23, 44534, Lünen, Germany.
Clin Res Cardiol. 2023 Jan;112(1):1-38. doi: 10.1007/s00392-022-02041-y. Epub 2022 Jun 4.
Currently, the term "heart failure with preserved left ventricular ejection fraction (HFpEF)" is based on echocardiographic parameters and clinical symptoms combined with elevated or normal levels of natriuretic peptides. Thus, "HFpEF" as a diagnosis subsumes multiple pathophysiological entities making a uniform management plan for "HFpEF" impossible. Therefore, a more specific characterization of the underlying cardiac pathologies in patients with preserved ejection fraction and symptoms of heart failure is mandatory. The present proposal seeks to offer practical support by a standardized echocardiographic workflow to characterize specific diagnostic entities associated with "HFpEF". It focuses on morphological and functional cardiac phenotypes characterized by echocardiography in patients with normal or preserved left ventricular ejection fraction (LVEF). The proposal discusses methodological issues to clarify why and when echocardiography is helpful to improve the diagnosis. Thus, the proposal addresses a systematic echocardiographic approach using a feasible algorithm with weighting criteria for interpretation of echocardiographic parameters related to patients with preserved ejection fraction and symptoms of heart failure. The authors consciously do not use the diagnosis "HFpEF" to avoid misunderstandings. Central illustration: Scheme illustrating the characteristic echocardiographic phenotypes and their combinations in patients with "HFpEF" symptoms with respect to the respective cardiac pathology and pathophysiology as well as the underlying typical disease.
目前,“射血分数保留的心力衰竭(HFpEF)”一词基于超声心动图参数和临床症状,并结合升高或正常的利钠肽水平。因此,“HFpEF”作为一种诊断包含多种病理生理实体,使得“HFpEF”不可能有统一的管理计划。因此,对于射血分数保留和心力衰竭症状的患者,必须对潜在的心脏病理学进行更具体的特征描述。本建议旨在通过标准化的超声心动图工作流程为特征明确的诊断实体提供实用支持,这些实体与“HFpEF”相关。它侧重于通过超声心动图在正常或保留的左心室射血分数(LVEF)的患者中特征化的形态和功能心脏表型。该建议讨论了方法学问题,以阐明为什么以及何时超声心动图有助于改善诊断。因此,该建议针对使用可行的算法和解释超声心动图参数的加权标准的系统超声心动图方法,这些参数与保留射血分数和心力衰竭症状的患者相关。作者有意识地不使用“HFpEF”诊断,以避免误解。中心插图:该图说明了“HFpEF”症状患者的特征性超声心动图表型及其组合,以及相应的心脏病理学和病理生理学,以及潜在的典型疾病。
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