Department of Medicine, Section of Infectious Diseases & Global Health, The University of Chicago, 5841 South Maryland Avenue, 5065, 60637, Chicago, MC, Illinois, United States.
Chicago Center for HIV Elimination, University of Chicago, Chicago, Illinois, United States.
AIDS Behav. 2022 Dec;26(12):3827-3833. doi: 10.1007/s10461-022-03711-8. Epub 2022 Jun 4.
PrEP uptake and adherence among young Black sexual minority men (YBSMM), has been sub-optimal. Multiple studies identified sleep as an important determinant of medication adherence, although it has not been examined with regard to PrEP among YBSMM. This study utilized data collected from HIV-negative cisgender YBSMM in the Neighborhoods and Networks (N2) study in Chicago using PrEP (N = 70). Sleep quality was measured using the PHQ-9 and PrEP adherence questions were adapted from Reynolds et al., 2004. Bivariate and multivariable regression analyses were used to estimate associations between sleep and missing PrEP doses, controlling for relevant demographic and behavioral factors. YBSMM who reported sleep disturbance a moderate amount of time (aOR 7.59 [1.05 to 54.57]) were more likely to miss taking PrEP because they had too many pills to take. Sleep quality is an overlooked determinant of medication adherence, and may negatively impact YBSMM's ability to consistently take PrEP.
在年轻的黑人性少数群体男性（YBSMM）中，接受和坚持使用暴露前预防（PrEP）的情况并不理想。多项研究确定睡眠是药物依从性的一个重要决定因素，尽管尚未针对 YBSMM 的 PrEP 进行检查。本研究利用在芝加哥进行的邻里和网络（N2）研究中收集的来自 HIV 阴性的顺性别 YBSMM 的数据，这些参与者正在使用 PrEP（N=70）。使用 PHQ-9 测量睡眠质量，PrEP 依从性问题改编自 Reynolds 等人，2004 年。使用双变量和多变量回归分析来估计睡眠与错过 PrEP 剂量之间的关联，控制相关的人口统计学和行为因素。报告有一定程度睡眠障碍的 YBSMM（aOR 7.59 [1.05 至 54.57]）更有可能错过服用 PrEP，因为他们需要服用太多的药丸。睡眠质量是药物依从性的一个被忽视的决定因素，可能会对 YBSMM 持续服用 PrEP 的能力产生负面影响。
