Instituto Nacional da Mulher, da Criança e do Adolescente Fernandes Figueira, Oswaldo Cruz Foundation, FIOCRUZ, Neonatology Rio de Janeiro/RJ, Brazil.
Applied Clinical Research, Instituto Nacional da Mulher, da Criança E do Adolescente Fernandes Figueira, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro/RJ, Brazil.
Eur J Pediatr. 2022 Aug;181(8):3039-3047. doi: 10.1007/s00431-022-04517-5. Epub 2022 Jun 4.
In this cross-sectional study, conducted in a cohort of infants with a gestational age of < 32 weeks, we aimed to evaluate and compare resting energy expenditure (REE) and body composition between infants who developed bronchopulmonary dysplasia (BPD) and those who did not. REE and body composition were assessed at term equivalent age using indirect calorimetry and air displacement plethysmography. Anthropometric measurements (weight, head circumference, and length) were obtained and transformed into Z-scores per the Fenton (2013) growth curve, at birth and at term equivalent age. Forty-two infants were included in this study, of which 26.2% developed BPD. Infants with BPD had significantly higher energy expenditure at term equivalent age, with no difference in body composition between the two groups.
Despite expending more energy, infants with BPD maintained a similar body composition distribution to those without BPD, and this is likely due to the recommended nutritional approach.
• Greater resting energy expenditure impairs growth of preterm infants with bronchopulmonary dysplasia.
• Although preterm infants with bronchopulmonary dysplasia had a higher resting energy expenditure at the corrected term age, this did not affect their body composition and growth.
本研究为一项对胎龄<32 周的婴儿进行的队列研究,旨在评估和比较发生支气管肺发育不良(BPD)与未发生 BPD 的婴儿之间的静息能量消耗(REE)和身体成分。采用间接热量法和空气置换体描法,在校正胎龄时评估 REE 和身体成分。在出生时和校正胎龄时,根据 Fenton(2013)生长曲线,获得体重、头围和身长等人体测量学指标,并将其转换为 Z 分数。本研究纳入了 42 名婴儿,其中 26.2%发生了 BPD。校正胎龄时,发生 BPD 的婴儿能量消耗显著更高,但两组之间的身体成分无差异。
尽管 BPD 婴儿的能量消耗更高,但与未发生 BPD 的婴儿相比,其身体成分分布相似,这可能是由于推荐的营养方法。
• 静息能量消耗增加会损害患有支气管肺发育不良的早产儿的生长。
• 尽管校正胎龄时患有 BPD 的早产儿的静息能量消耗更高,但这并未影响其身体成分和生长。