Institute of Metabolism and Systems Research, Tommy's National Centre for Miscarriage Research, University of Birmingham, Birmingham, B15 2TT, UK.
Institute of Applied Health Research, Room 232 Murray Learning Centre, University of Birmingham, Birmingham, B15 2FG, UK.
Endocrinol Metab Clin North Am. 2022 Jun;51(2):417-436. doi: 10.1016/j.ecl.2021.12.005. Epub 2022 May 4.
Thyroid disease is associated with adverse maternal and fetal outcomes. Appropriate reference ranges should be used for the interpretation of test results, although universal screening for thyroid dysfunction is not warranted. Overt thyroid dysfunction requires careful consideration of medication adjustments and close monitoring. Mild thyroid hypofunction has been linked to adverse pregnancy outcomes including preterm delivery, and poor neurocognition in the offspring. This review summarizes the most recent evidence on the counseling and management of women with thyroid disease before and during pregnancy and highlights the areas of controversy in need of further research.
甲状腺疾病与不良的母婴结局相关。尽管普遍筛查甲状腺功能障碍没有依据,但应使用适当的参考范围来解读检测结果。显性甲状腺功能障碍需要仔细考虑药物调整和密切监测。轻度甲状腺功能减退与不良的妊娠结局有关,包括早产和后代的神经认知能力差。本综述总结了关于甲状腺疾病女性在妊娠前后的咨询和管理的最新证据,并强调了需要进一步研究的争议领域。