Al-Kuraishy Hayder M, Al-Gareeb Ali I, Fageyinbo Muyiwa Samuel, Batiha Gaber El-Saber
Department of Clinical Pharmacology & Therapeutics medicine, College of Medicine, AL-Mustansiriyiah University, Baghdad, Iraq.
Department of Pharmacology & Therapeutics, Faculty of Basic Clinical Sciences, University of Medical Sciences, Ondo City, Ondo State, PMB 536, Nigeria.
Future Sci OA. 2022 Apr 14;8(5):FSO797. doi: 10.2144/fsoa-2021-0099. eCollection 2022 Mar.
Vinpocetine (VPN) is an alkaloid derivative of vincamine inhibits phosphodiesterase type 1 that increase cyclic guanosine monophosphate and cyclic adenosine monophosphate. VPN have anti-inflammatory and antioxidant effects with suppression release of pro-inflammatory cytokines. Moreover, VPN mitigates oxidative stress (OS) and inflammatory reactions through inhibition of mitogen-activated protein kinase (MAPK) signaling pathway. Therefore, VPN may decrease hyper-inflammation-induced acute lung injury in COVID-19 through modulation of NF-κB pathway. Taken together, VPN has pulmonary and extra-pulmonary protective effects against COVID-19 through mitigation of OS and hyperinflammation. In conclusion, VPN has noteworthy anti-inflammatory and anti-oxidant effects through inhibition of NF-κB/MAPK signaling pathway so, it may reduce SARS-CoV-2-induced hyper inflammatory and OS.
长春西汀（Vinpocetine，VPN）是长春胺的生物碱衍生物，可抑制1型磷酸二酯酶，增加环磷酸鸟苷和环磷酸腺苷。VPN具有抗炎和抗氧化作用，可抑制促炎细胞因子的释放。此外，VPN通过抑制丝裂原活化蛋白激酶（MAPK）信号通路减轻氧化应激（OS）和炎症反应。因此，VPN可能通过调节NF-κB途径减轻COVID-19中过度炎症诱导的急性肺损伤。综上所述，VPN通过减轻OS和过度炎症对COVID-19具有肺内和肺外保护作用。总之，VPN通过抑制NF-κB/MAPK信号通路具有显著的抗炎和抗氧化作用，因此，它可能减轻SARS-CoV-2诱导的过度炎症和OS。
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