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长春西汀的临床药理学：特性再探讨及其代谢产物阿朴长春胺酸（AVA）群体药代动力学模型的介绍。

Clinical Pharmacology of Vinpocetine: Properties Revisited and Introduction of a Population Pharmacokinetic Model for Its Metabolite, Apovincaminic Acid (AVA).

作者信息

Petric Zvonimir, Paixão Paulo, Filipe Augusto, Guimarães Morais José

机构信息

Department of Pharmacological Sciences, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, 1649-004 Lisboa, Portugal.

Medical Department, Tecnimede, Sociedade Técnico-Medicinal, S.A., Zona Industrial da Abrunheira, Rua da Tapada Grande, No. 2 Abrunheira, 2710-089 Sintra, Portugal.

出版信息

Pharmaceutics. 2023 Oct 20;15(10):2502. doi: 10.3390/pharmaceutics15102502.

DOI:10.3390/pharmaceutics15102502
PMID:37896263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10610279/
Abstract

This paper examines the use of vinpocetine in the context of clinical pharmacology. The main and active metabolite of vinpocetine is apovincaminic acid (AVA). Due to the scarce information in the literature on AVA pharmacokinetics, we propose a population pharmacokinetic (PopPK) model for AVA based on a study in healthy volunteers with three different formulations of vinpocetine. The suggested PopPK model (and simulations) could be helpful in ensuring the more effective and safer use of the vinpocetine in the future given the increasing range of suggested indications for its use.

摘要

本文研究了长春西汀在临床药理学背景下的应用。长春西汀的主要活性代谢产物是阿朴长春胺酸（AVA）。由于文献中关于AVA药代动力学的信息稀缺，我们基于一项针对健康志愿者使用三种不同剂型长春西汀的研究，提出了一个AVA的群体药代动力学（PopPK）模型。鉴于长春西汀建议使用的适应症范围不断扩大，所建议的PopPK模型（及模拟）可能有助于确保未来更有效、更安全地使用长春西汀。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/59c7c2015c95/pharmaceutics-15-02502-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/115c9a7ac479/pharmaceutics-15-02502-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/7b08beba2686/pharmaceutics-15-02502-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/12cf353e4b75/pharmaceutics-15-02502-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/100d764ee61f/pharmaceutics-15-02502-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/59c7c2015c95/pharmaceutics-15-02502-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/115c9a7ac479/pharmaceutics-15-02502-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/7b08beba2686/pharmaceutics-15-02502-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/12cf353e4b75/pharmaceutics-15-02502-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/100d764ee61f/pharmaceutics-15-02502-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c841/10610279/59c7c2015c95/pharmaceutics-15-02502-g005a.jpg

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Clinical Pharmacology of Vinpocetine: Properties Revisited and Introduction of a Population Pharmacokinetic Model for Its Metabolite, Apovincaminic Acid (AVA).长春西汀的临床药理学：特性再探讨及其代谢产物阿朴长春胺酸（AVA）群体药代动力学模型的介绍。
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Pharmaceutics. 2022 Aug 24;14(9):1766. doi: 10.3390/pharmaceutics14091766.
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Nootropics as Cognitive Enhancers: Types, Dosage and Side Effects of Smart Drugs.益智药作为认知增强剂：智能药物的类型、剂量和副作用。
Nutrients. 2022 Aug 17;14(16):3367. doi: 10.3390/nu14163367.
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Evaluating the neuroprotective activities of vinpocetine, punicalagin, niacin and vitamin E against behavioural and motor disabilities of manganese-induced Parkinson's disease in Sprague Dawley rats.
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AMB Express. 2024 Aug 2;14(1):89. doi: 10.1186/s13568-024-01731-2.
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Foods. 2024 Mar 16;13(6):908. doi: 10.3390/foods13060908.
评价长春西汀、鞣花酸、烟酸和维生素 E 对锰诱导的 Sprague Dawley 大鼠帕金森病行为和运动障碍的神经保护活性。
Biomed Pharmacother. 2022 Sep;153:113330. doi: 10.1016/j.biopha.2022.113330. Epub 2022 Jun 30.
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