Petric Zvonimir, Paixão Paulo, Filipe Augusto, Guimarães Morais José
Department of Pharmacological Sciences, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, 1649-004 Lisboa, Portugal.
Medical Department, Tecnimede, Sociedade Técnico-Medicinal, S.A., Zona Industrial da Abrunheira, Rua da Tapada Grande, No. 2 Abrunheira, 2710-089 Sintra, Portugal.
Pharmaceutics. 2023 Oct 20;15(10):2502. doi: 10.3390/pharmaceutics15102502.
This paper examines the use of vinpocetine in the context of clinical pharmacology. The main and active metabolite of vinpocetine is apovincaminic acid (AVA). Due to the scarce information in the literature on AVA pharmacokinetics, we propose a population pharmacokinetic (PopPK) model for AVA based on a study in healthy volunteers with three different formulations of vinpocetine. The suggested PopPK model (and simulations) could be helpful in ensuring the more effective and safer use of the vinpocetine in the future given the increasing range of suggested indications for its use.
本文研究了长春西汀在临床药理学背景下的应用。长春西汀的主要活性代谢产物是阿朴长春胺酸（AVA）。由于文献中关于AVA药代动力学的信息稀缺，我们基于一项针对健康志愿者使用三种不同剂型长春西汀的研究，提出了一个AVA的群体药代动力学（PopPK）模型。鉴于长春西汀建议使用的适应症范围不断扩大，所建议的PopPK模型（及模拟）可能有助于确保未来更有效、更安全地使用长春西汀。
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