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使用未培养的脐带间充质干细胞治疗脊髓空洞症:一例病例报告及文献综述

Treatment of syringomyelia using uncultured umbilical cord mesenchymal stem cells: A case report and review of literature.

作者信息

Ahn Hyunjun, Lee Sang Yeon, Jung Won-Ju, Lee Kye-Ho

机构信息

Stem Cell Treatment and Research Institute (STRI), bio Beauty and Health Company (bBHC), Seoul 04420, South Korea.

Stem Cell Treatment, 97.7 Beauty and Health Clinic, Seoul 04420, South Korea.

出版信息

World J Stem Cells. 2022 Apr 26;14(4):303-309. doi: 10.4252/wjsc.v14.i4.303.

DOI:10.4252/wjsc.v14.i4.303
PMID:35662863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9136562/
Abstract

BACKGROUND

Syringomyelia is a disease caused by the formation of a cavity inside the spinal cord and is accompanied by such symptoms as pain, paresthesia, and urination and defecation disorders, and in severe cases causes various paralyses. Currently, there are only surgical methods for the treatment of syringomyelia, but these methods carry the possibility of failure, recurrence, and side effects.

CASE SUMMARY

The patient was a 59-year-old woman who suffered from pain due to syringomyelia. For treatment, the patient received transplant of uncultured umbilical cord-derived mesenchymal stem cells. As intended, the patient's pain was relieved after treatment. Interestingly, an additional benefit was found in that the size of the cavity also decreased. After 2 years from the last treatment, the patient's cavity had almost completely disappeared and her syringomyelia was deemed cured.

CONCLUSION

Using uncultured umbilical cord-derived mesenchymal stem cells may be a new treatment alternative for syringomyelia.

摘要

背景

脊髓空洞症是一种由脊髓内形成空洞引起的疾病,伴有疼痛、感觉异常以及排尿和排便障碍等症状,严重时会导致各种瘫痪。目前,治疗脊髓空洞症仅有手术方法,但这些方法存在失败、复发和副作用的可能性。

病例摘要

该患者为一名59岁女性,因脊髓空洞症而疼痛。为进行治疗,患者接受了未培养的脐带间充质干细胞移植。治疗后,患者的疼痛如预期般得到缓解。有趣的是,还发现了一个额外的益处,即空洞的大小也减小了。在最后一次治疗两年后,患者的空洞几乎完全消失,其脊髓空洞症被认为已治愈。

结论

使用未培养的脐带间充质干细胞可能是脊髓空洞症的一种新的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df0/9136562/86e0c041ecc9/WJSC-14-303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df0/9136562/86e0c041ecc9/WJSC-14-303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df0/9136562/86e0c041ecc9/WJSC-14-303-g001.jpg

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