Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):155-63. doi: 10.1007/s10911-013-9280-x. Epub 2013 May 10.
The first member of the Wnt-family ligands was identified 30 years ago as a factor in mouse mammary tumours whose expression was deregulated due to the promoter activity emanating from the proximal integration of the Mouse Mammary Tumour Virus genome (Nusse and Varmus, Embo J 31:2670-84, 2012). The Wnt-ligands invoke a number of molecular-genetic signalling cascades fundamental to the patterning of developing tissues and organs during embryogenesis as well as during postnatal development. The Wnt-signalling cascade that controls the activities of β-catenin and the T-cell Factor (Tcf)/Lympoid enhancer factor (Lef1) plays a fundamental role in control of all stages of embryonic mammary gland development. We provide here a brief overview of the known aspects of Wnt-signalling activities in the embryonic mammary gland and its interactions with other signalling cascades in this developing tissue.
Wnt 家族配体的第一个成员是 30 年前在小鼠乳腺肿瘤中被鉴定出来的，由于小鼠乳腺肿瘤病毒基因组近端整合产生的启动子活性，其表达被失调（Nusse 和 Varmus，Embo J 31:2670-84, 2012）。Wnt 配体引发了许多分子遗传信号级联反应，这些反应对于胚胎发生过程中以及出生后组织和器官的形成至关重要。Wnt 信号级联反应控制β-catenin 和 T 细胞因子（Tcf）/淋巴增强因子（Lef1）的活性，在控制胚胎乳腺发育的所有阶段中起着重要作用。在这里，我们简要概述了已知的 Wnt 信号在胚胎乳腺中的作用及其与该发育组织中其他信号级联的相互作用。
