Ogata M, Kenmotsu K, Hirota N, Meguro T, Aikoh H
Arch Environ Health. 1987 Jan-Feb;42(1):26-30. doi: 10.1080/00039896.1987.9935791.
A significant difference in the amount of exhaled mercury per hour between normal and acatalasemic mice was observed in 7 of 11 experiments for different periods of time. The total amount of mercury exhaled from acatalasemic mice was significantly higher than those of normal mice. The results confirm that the reduction of mercuric ion to metallic mercury occurs by recycling of mercury in the tissues and reoxidized metallic mercury to mercuric ion by catalase. Mercuric ion was reduced to metallic mercury in the presence of superoxide anion in vitro. The reduction rate of mercuric ion to metallic mercury in the presence of both superoxide anion and cytochrome C or nitro blue tetrazolium was higher than that in the presence of superoxide anion alone, and the reduction of mercuric ion by NADPH or NADH was also observed. The reduction of mercuric ion to metallic mercury by liver homogenates of acatalasemic mice was higher than that of normal mice.
在11项实验中的7项实验里，在不同时间段观察到正常小鼠和无过氧化氢酶小鼠每小时呼出汞量存在显著差异。无过氧化氢酶小鼠呼出的汞总量显著高于正常小鼠。结果证实，汞离子还原为金属汞是通过组织中汞的循环以及过氧化氢酶将再氧化的金属汞还原为汞离子实现的。在体外，汞离子在超氧阴离子存在的情况下还原为金属汞。在超氧阴离子与细胞色素C或硝基蓝四氮唑同时存在时，汞离子还原为金属汞的速率高于仅存在超氧阴离子时，并且还观察到了NADPH或NADH对汞离子的还原作用。无过氧化氢酶小鼠肝脏匀浆将汞离子还原为金属汞的能力高于正常小鼠。
