Shan Xinying, Li Jialu, Zeng Lingjing, Wang Haiteng, Yang Tianyi, Shao Yongcong, Yu Mengsun
School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Center for Rehabilitation Technical Aids, Beijing, China.
Front Neurosci. 2022 May 19;16:799995. doi: 10.3389/fnins.2022.799995. eCollection 2022.
An amputation is known to seriously affect patient quality of life. This study aimed to investigate changes in neural activity in amputees during the postoperative period using neural electrophysiological techniques. In total, 14 patients with left lower limb amputation and 18 healthy participants were included in our study. All participants were required to perform motor imagery paradigm tasks while electroencephalogram (EEG) data were recorded. Data analysis results indicated that the beta frequency band showed significantly decreased oscillatory activity in motor imaging-related brain regions such as the frontal lobe and the precentral and postcentral gyri in amputees. Furthermore, the functional independent component analysis (fICA) value of neural oscillation negatively correlated with the C4 electrode power value of the motor imagery task in amputees ( < 0.05). Therefore, changes in neural oscillations and beta frequency band in motor imagery regions may be related to brain remodeling in amputees.
已知截肢会严重影响患者的生活质量。本研究旨在采用神经电生理技术，调查截肢患者术后神经活动的变化。我们的研究共纳入了14例左下肢截肢患者和18名健康参与者。所有参与者在进行运动想象范式任务时均需记录脑电图（EEG）数据。数据分析结果表明，β频段在截肢患者的额叶、中央前回和中央后回等与运动想象相关的脑区的振荡活动显著降低。此外，截肢患者神经振荡的功能独立成分分析（fICA）值与运动想象任务的C4电极功率值呈负相关（<0.05）。因此，运动想象区域的神经振荡和β频段变化可能与截肢患者的大脑重塑有关。
